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prkcz protein kinase C, zeta [ Danio rerio (zebrafish) ]

Gene ID: 555737, updated on 11-Apr-2024

Summary

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Official Symbol
prkczprovided by ZNC
Official Full Name
protein kinase C, zetaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070511-1
See related
Ensembl:ENSDARG00000043332 AllianceGenome:ZFIN:ZDB-GENE-070511-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pkcz; si:ch211-150o23.4
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including animal organ development; photoreceptor cell outer segment organization; and regulation of cell migration involved in sprouting angiogenesis. Is expressed in nervous system and neuroepithelial cell. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 8
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (17548292..17772685, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (17516065..17737005, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene v-ski avian sarcoma viral oncogene homolog a Neighboring gene si:ch73-70k4.1 Neighboring gene si:ch211-150o23.3 Neighboring gene si:ch211-150o23.2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting. Oubaha M, et al. Blood, 2012 Oct 18. PMID 22936663, Free PMC Article
  2. Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. Baye LM, et al. J Neurosci, 2007 Sep 19. PMID 17881520, Free PMC Article
  3. Analysis of aPKClambda and aPKCzeta reveals multiple and redundant functions during vertebrate retinogenesis. Cui S, et al. Mol Cell Neurosci, 2007 Mar. PMID 17223574, Free PMC Article
  4. Interkinetic nuclear migration is centrosome independent and ensures apical cell division to maintain tissue integrity. Strzyz PJ, et al. Dev Cell, 2015 Jan 26. PMID 25600237
  5. Syntaxin 16 regulates lumen formation during epithelial morphogenesis. Jung JJ, et al. PLoS One, 2013. PMID 23626741, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
    Title: Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dermal bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within generation of neurons IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nuclear migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within photoreceptor cell outer segment organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pronephric nephron tubule epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina morphogenesis in camera-type eye IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C zeta type
Names
atypical protein kinase C zeta
NP_001025262.1
XP_009302121.1
XP_009302122.1
XP_009302124.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030091.1 → NP_001025262.1  protein kinase C zeta type

    See identical proteins and their annotated locations for NP_001025262.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ097196
    UniProtKB/TrEMBL
    Q4JG04
    Related
    ENSDARP00000063591.4, ENSDART00000063592.5
    Conserved Domains (4) summary
    smart00220
    Location:259 → 525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05617
    Location:243 → 599
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    pfam00130
    Location:131 → 183
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02720
    Location:16 → 98
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    17548292..17772685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009303846.3 → XP_009302121.1  protein kinase C zeta type isoform X1

    UniProtKB/TrEMBL
    A0A8M3B1V2
    Conserved Domains (4) summary
    smart00220
    Location:259 → 529
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05617
    Location:243 → 603
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    pfam00130
    Location:131 → 183
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02720
    Location:16 → 98
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

  2. XM_009303849.3 → XP_009302124.1  protein kinase C zeta type isoform X3

    UniProtKB/TrEMBL
    A0A8M3BBP0
    Conserved Domains (2) summary
    smart00220
    Location:76 → 346
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:60 → 420
    PKc_like; Protein Kinases, catalytic domain

  3. XM_009303847.3 → XP_009302122.1  protein kinase C zeta type isoform X2

    UniProtKB/TrEMBL
    A0A8M3AV14
    Conserved Domains (3) summary
    smart00220
    Location:160 → 430
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05617
    Location:144 → 504
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    pfam00130
    Location:32 → 84
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394717.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    93575..290477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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