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prkcq protein kinase C, theta [ Danio rerio (zebrafish) ]

Gene ID: 555521, updated on 11-Apr-2024

Summary

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Official Symbol
prkcqprovided by ZNC
Official Full Name
protein kinase C, thetaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-195
See related
Ensembl:ENSDARG00000034173 AllianceGenome:ZFIN:ZDB-GENE-041210-195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-239o15.1
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within protein phosphorylation. Located in immunological synapse. Is expressed in Mauthner neurons; brain; somite border; and spinal cord. Orthologous to human PRKCQ (protein kinase C theta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See prkcq in Genome Data Viewer
Location:
chromosome: 4
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (25408325..25443364)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (25402023..25453607)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 110, like Neighboring gene Scm like with four mbt domains 2 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Neighboring gene RNA binding motif protein 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterisation of amphioxus protein kinase C-δ/θ reveals a unique proto-V3 domain suggesting an evolutionary mechanism for PKC-θ unique V3. Chen ZL, et al. Fish Shellfish Immunol, 2019 Jan. PMID 30408601
  2. Differential expression of PKC isoforms in developing zebrafish. Patten SA, et al. Int J Dev Neurosci, 2007 May. PMID 17403595
  3. Expression and localization of grass carp pkc-θ (protein kinase C theta) gene after its activation. Mehjabin R, et al. Fish Shellfish Immunol, 2019 Apr. PMID 30716520
  4. Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq. Pandey S, et al. Curr Biol, 2018 Apr 2. PMID 29576475, Free PMC Article
  5. Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection. Lin C, et al. BMC Syst Biol, 2014. PMID 25603810, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in immunological synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C theta type
NP_001082839.2
XP_009298659.1
XP_009298660.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089370.2 → NP_001082839.2  protein kinase C theta type

    See identical proteins and their annotated locations for NP_001082839.2

    Status: VALIDATED

    Source sequence(s)
    AL954652
    UniProtKB/TrEMBL
    A0A8M1NE42, F1R506
    Related
    ENSDARP00000046252.5, ENSDART00000046253.5
    Conserved Domains (3) summary
    smart00220
    Location:386 → 640
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05619
    Location:380 → 710
    STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta
    pfam00130
    Location:232 → 284
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    25408325..25443364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009300385.3 → XP_009298660.1  protein kinase C theta type isoform X1

    See identical proteins and their annotated locations for XP_009298660.1

    UniProtKB/TrEMBL
    A0A8M3B909
    Conserved Domains (3) summary
    smart00220
    Location:392 → 646
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05619
    Location:386 → 716
    STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta
    pfam00130
    Location:238 → 290
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. XM_009300384.3 → XP_009298659.1  protein kinase C theta type isoform X1

    See identical proteins and their annotated locations for XP_009298659.1

    UniProtKB/TrEMBL
    A0A8M3B909
    Related
    ENSDARP00000108813.2, ENSDART00000123680.3
    Conserved Domains (3) summary
    smart00220
    Location:392 → 646
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05619
    Location:386 → 716
    STKc_nPKC_theta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta
    pfam00130
    Location:238 → 290
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein Strain
Heading Accession and Version

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