spra sepiapterin reductase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: spraprovided by ZNC
Official Full Name: sepiapterin reductase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-412
See related: Ensembl:ENSDARG00000004406 AllianceGenome:ZFIN:ZDB-GENE-050522-412
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: spr; fj86h06; wu:fj86h06; zgc:112298
Summary: Predicted to enable sepiapterin reductase activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Is expressed in diencephalon; melanocyte; midbrain hindbrain boundary; and presumptive neural retina. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (72129708..72136593, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (71345202..71352087, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The zebrafish mutation m865 affects formation of dopaminergic neurons and neuronal survival, and maps to a genetic interval containing the sepiapterin reductase locus.
Title: The zebrafish mutation m865 affects formation of dopaminergic neurons and neuronal survival, and maps to a genetic interval containing the sepiapterin reductase locus.

Submit: New GeneRIF Correction

General gene information

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Markers

fa66b04 (e-PCR)
- UniSTS:188832

fj86h06.x1 (e-PCR)
- UniSTS:200169

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables sepiapterin reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sepiapterin reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tetrahydrobiopterin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tetrahydrobiopterin biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sepiapterin reductase a

NP_001019601.2

EC 1.1.1.153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024430.2 → NP_001019601.2 sepiapterin reductase a

Status: VALIDATED

Source sequence(s)

CU929062

UniProtKB/TrEMBL

A0A8M1N6P5, F1QWX4

Related

ENSDARP00000002775.7, ENSDART00000007827.8

Conserved Domains (2) summary

cd05367
Location:11 → 260

SPR-like_SDR_c; sepiapterin reductase (SPR)-like, classical (c) SDRs

pfam00106
Location:12 → 211

adh_short; short chain dehydrogenase