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mapk15 mitogen-activated protein kinase 15 [ Danio rerio (zebrafish) ]

Gene ID: 553780, updated on 27-Mar-2024

Summary

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Official Symbol
mapk15provided by ZNC
Official Full Name
mitogen-activated protein kinase 15provided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-307
See related
Ensembl:ENSDARG00000100822 AllianceGenome:ZFIN:ZDB-GENE-050522-307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
erk7; zgc:110345
Summary
Predicted to enable MAP kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Kupffer's vesicle; basal plate midbrain region; forerunner cell group; nervous system; and pronephric duct. Orthologous to human MAPK15 (mitogen-activated protein kinase 15). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (46240165..46257880)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (46647913..46665625)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene VPS28 subunit of ESCRT-I Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding) Neighboring gene solute carrier family 30 member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization and expression patterns of the MAPK family in zebrafish. Krens SF, et al. Gene Expr Patterns, 2006 Oct. PMID 16774848
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC110345

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 15
Names
extracellular signal-regulated kinase 7
NP_001018581.2
XP_009292731.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020745.2 → NP_001018581.2  mitogen-activated protein kinase 15

    Status: VALIDATED

    Source sequence(s)
    CU633987
    UniProtKB/TrEMBL
    A0A0R4IIR5, A0A8M1N660
    Related
    ENSDARP00000135500.1, ENSDART00000162785.2
    Conserved Domains (2) summary
    smart00220
    Location:14 → 305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:6 → 344
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    46240165..46257880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294456.2 → XP_009292731.1  mitogen-activated protein kinase 15 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AL82
    Conserved Domains (2) summary
    smart00220
    Location:14 → 305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:6 → 344
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
Nucleotide Protein
Heading Accession and Version

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