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scdb stearoyl-CoA desaturase b [ Danio rerio (zebrafish) ]

Gene ID: 553734, updated on 14-Apr-2024

Summary

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Official Symbol
scdbprovided by ZNC
Official Full Name
stearoyl-CoA desaturase bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-12
See related
Ensembl:ENSDARG00000030265 AllianceGenome:ZFIN:ZDB-GENE-050522-12
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:112951
Summary
Predicted to enable iron ion binding activity; palmitoyl-CoA 9-desaturase activity; and stearoyl-CoA 9-desaturase activity. Predicted to be involved in monounsaturated fatty acid biosynthetic process; response to fatty acid; and unsaturated fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in brain and muscle. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See scdb in Genome Data Viewer
Location:
chromosome: 13
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (30009617..30027708, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (29877709..29897216, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene hypoxia inducible factor 1 subunit alpha inhibitor Neighboring gene wingless-type MMTV integration site family, member 8b Neighboring gene DnaJ heat shock protein family (Hsp40) member B12a Neighboring gene tRNA methyltransferase 2 homolog B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ancient and modern duplication events and the evolution of stearoyl-CoA desaturases in teleost fishes. Evans H, et al. Physiol Genomics, 2008 Sep 17. PMID 18593860, Free PMC Article
  2. Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy. Raas Q, et al. J Clin Invest, 2021 Apr 15. PMID 33690217, Free PMC Article
  3. A Model Construction of Starvation Induces Hepatic Steatosis and Transcriptome Analysis in Zebrafish Larvae. Xu H, et al. Biology (Basel), 2021 Jan 27. PMID 33513687, Free PMC Article
  4. Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish. Cinaroglu A, et al. Hepatology, 2011 Aug. PMID 21538441, Free PMC Article
  5. [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Fei F, et al. Sheng Li Xue Bao, 2017 Feb 25. PMID 28217809

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC112951

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables stearoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in monounsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within swimming behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in unsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
stearoyl-CoA desaturase b
Names
SCD2
NP_001018541.1
XP_005156902.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020705.1 → NP_001018541.1  stearoyl-CoA desaturase b

    See identical proteins and their annotated locations for NP_001018541.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095851
    UniProtKB/TrEMBL
    A0A8M1N6D3, Q501V8
    Related
    ENSDARP00000147880.1, ENSDART00000183889.1
    Conserved Domains (2) summary
    cd03505
    Location:54 → 294
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:58 → 262
    FA_desaturase; Fatty acid desaturase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    30009617..30027708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156845.4 → XP_005156902.1  stearoyl-CoA desaturase b isoform X1

    UniProtKB/TrEMBL
    A0A8M2B301
    Conserved Domains (2) summary
    cd03505
    Location:118 → 358
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:122 → 326
    FA_desaturase; Fatty acid desaturase
Nucleotide Protein Strain
Heading Accession and Version

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