klf7a Kruppel like factor 7a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: klf7aprovided by ZNC
Official Full Name: Kruppel like factor 7aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-276
See related: Ensembl:ENSDARG00000073857 AllianceGenome:ZFIN:ZDB-GENE-050522-276
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: klf7; zgc:112027
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in brain and olfactory system. Orthologous to human KLF7 (Kruppel like factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (6403562..6494384, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (5705575..5796397, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the spinal cord, klf7- and klf6a-expressing cells are found in both the dorsal and ventral horns. Numerous sensory structures (e.g. auditory, lateral line, olfactory and visual) and several motor nuclei (e.g. oculomotor, trigeminal, and vagal motor nuclei) contain klf7- and/or klf6a-expressing cells
Title: Krüpple-like factors 7 and 6a mRNA expression in adult zebrafish central nervous system.
Data revealed that expression of DNA binding inhibitor 3, early B cell factor 2, Ebf3, Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein 7 and stathmin-like 4,were enriched in the diencephalon of zebrafish.
Title: Expression of ventral diencephalon-enriched genes in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryo development	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Krueppel-like factor 7a

Names: Kruppel-like factor 7 (ubiquitous)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020643.1 → NP_001018479.1 Krueppel-like factor 7a

See identical proteins and their annotated locations for NP_001018479.1

Status: PROVISIONAL

Source sequence(s)

BC095648

UniProtKB/TrEMBL

Q502L8

Related

ENSDARP00000103603.1, ENSDART00000109356.3

Conserved Domains (3) summary

COG5048
Location:197 → 268

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:208 → 227

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:249 → 274

zf-H2C2_2; Zinc-finger double domain