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PPP5C protein phosphatase 5 catalytic subunit [ Homo sapiens (human) ]

Gene ID: 5536, updated on 4-Jan-2025

Summary

Official Symbol
PPP5Cprovided by HGNC
Official Full Name
protein phosphatase 5 catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:9322
See related
Ensembl:ENSG00000011485 MIM:600658; AllianceGenome:HGNC:9322
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP5; PPT; PPP5
Summary
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in heart (RPKM 18.5), brain (RPKM 17.4) and 25 other tissues See more
Orthologs
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Genomic context

See PPP5C in Genome Data Viewer
Location:
19q13.32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46347087..46390975)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49174533..49218356)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46850344..46894232)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46763899-46764398 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:46765735-46766934 Neighboring gene Sharpr-MPRA regulatory region 13463 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46774457-46775170 Neighboring gene IGF like family member 1 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46806397-46806980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46806981-46807564 Neighboring gene hypoxia inducible factor 3 subunit alpha Neighboring gene RNA, U6 small nuclear 924, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46823333-46823834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46823835-46824334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46854004-46854805 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10811 Neighboring gene uncharacterized LOC105372426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46886025-46886926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46896972-46897472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46906697-46907404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46911937-46912461 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46915195-46916028 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:46917695-46918528 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46918529-46919361 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46929872-46930378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46929364-46929871 Neighboring gene coiled-coil domain containing 8 Neighboring gene PNMA family member 8C

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ36922, FLJ55954

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding PubMed 
enables ATP binding PubMed 
enables Hsp90 protein binding PubMed 
enables MAP kinase serine/threonine phosphatase activity  
enables RNA binding  
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
enables calmodulin-dependent protein phosphatase activity  
enables histone H2AXS140 phosphatase activity  
enables identical protein binding PubMed 
enables lipid binding  
enables metal ion binding  
enables myosin phosphatase activity  
enables phosphatase activity PubMed 
enables phosphoprotein phosphatase activity PubMed 
enables phosphoprotein phosphatase activity PubMed 
enables protein binding PubMed 
enables protein serine/threonine phosphatase activity  
enables protein serine/threonine phosphatase activity PubMed 
enables protein serine/threonine phosphatase activity PubMed 
enables protein serine/threonine phosphatase activity PubMed 
enables tau protein binding PubMed 
Component Evidence Code Pubs
is_active_in cytosol  
located_in cytosol  
located_in cytosol  
located_in intracellular membrane-bounded organelle  
located_in nucleoplasm  
is_active_in nucleus  
located_in plasma membrane  
part_of protein folding chaperone complex PubMed 
part_of protein-containing complex PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 5
Names
PP-T
protein phosphatase T
NP_001191213.1
NP_006238.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028163.1 RefSeqGene

    Range
    5094..48982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204284.2NP_001191213.1  serine/threonine-protein phosphatase 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AC007193, DA545760
    UniProtKB/TrEMBL
    B2R6R6, Q53FR0
    Conserved Domains (7) summary
    smart00028
    Location:2861
    TPR; Tetratricopeptide repeats
    smart00156
    Location:212458
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    sd00006
    Location:2856
    TPR; TPR repeat [structural motif]
    cd07417
    Location:176469
    MPP_PP5_C; PP5, C-terminal metallophosphatase domain
    pfam08321
    Location:138211
    PPP5; PPP5 TPR repeat region
    pfam13371
    Location:71134
    TPR_9; Tetratricopeptide repeat
    pfam13414
    Location:2793
    TPR_11; TPR repeat
  2. NM_006247.4NP_006238.1  serine/threonine-protein phosphatase 5 isoform 1

    See identical proteins and their annotated locations for NP_006238.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC007193, BC001970
    Consensus CDS
    CCDS12684.1
    UniProtKB/Swiss-Prot
    P53041, Q16722, Q53XV2
    UniProtKB/TrEMBL
    B2R6R6, Q53FR0
    Related
    ENSP00000012443.4, ENST00000012443.9
    Conserved Domains (7) summary
    smart00028
    Location:2861
    TPR; Tetratricopeptide repeats
    smart00156
    Location:204480
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    sd00006
    Location:2856
    TPR; TPR repeat [structural motif]
    cd15830
    Location:38153
    BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery
    cd07417
    Location:176491
    MPP_PP5_C; PP5, C-terminal metallophosphatase domain
    pfam13371
    Location:71134
    TPR_9; Tetratricopeptide repeat
    pfam13414
    Location:2793
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46347087..46390975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    49174533..49218356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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