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gsr glutathione reductase [ Danio rerio (zebrafish) ]

Gene ID: 553575, updated on 14-Apr-2024

Summary

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Official Symbol
gsrprovided by ZNC
Official Full Name
glutathione reductaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-116
See related
Ensembl:ENSDARG00000019236 AllianceGenome:ZFIN:ZDB-GENE-050522-116
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110010
Summary
Predicted to enable flavin adenine dinucleotide binding activity and glutathione-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis; cellular response to oxidative stress; and glutathione metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in intestinal bulb; liver; and macrophage. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (38852969..38873125, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (38512655..38532821, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A0b Neighboring gene heterogeneous nuclear ribonucleoprotein A0, like Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit VII Neighboring gene translocase of inner mitochondrial membrane 8 homolog A (yeast)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Sodium benzoate induced developmental defects, oxidative stress and anxiety-like behaviour in zebrafish larva. Gaur H, et al. Biochem Biophys Res Commun, 2018 Jul 20. PMID 29842881
  2. In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy. Díaz-Casado ME, et al. Zebrafish, 2018 Feb. PMID 29185873
  3. Editor's Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models. Poon KL, et al. Toxicol Sci, 2017 Mar 1. PMID 28069987
  4. Dietary inclusion of royal jelly modulates gene expression and activity of oxidative stress enzymes in zebrafish. Aksakal E, et al. J Enzyme Inhib Med Chem, 2021 Dec. PMID 33752574, Free PMC Article
  5. Gene expression patterns and related enzymatic activities of detoxification and oxidative stress systems in zebrafish larvae exposed to the 2,4-dichlorophenoxyacetic acid herbicide. Gaaied S, et al. Chemosphere, 2019 Jun. PMID 30825855

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC110010

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables glutathione-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutathione reductase, mitochondrial
NP_001018390.1
XP_005169649.1
XP_017214504.1
XP_021336698.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020554.1 → NP_001018390.1  glutathione reductase, mitochondrial

    See identical proteins and their annotated locations for NP_001018390.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095128
    UniProtKB/TrEMBL
    Q503Y5
    Related
    ENSDARP00000047049.6, ENSDART00000047050.8
    Conserved Domains (3) summary
    TIGR01421
    Location:25 → 425
    gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
    pfam00070
    Location:177 → 253
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:313 → 423
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    38852969..38873125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169592.4 → XP_005169649.1  glutathione reductase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z2M1, E7FGA5
    Conserved Domains (3) summary
    TIGR01421
    Location:56 → 500
    gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
    pfam00070
    Location:208 → 284
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:390 → 498
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

  2. XM_021481023.1 → XP_021336698.1  glutathione reductase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8M9QB21
    Conserved Domains (1) summary
    cl27343
    Location:25 → 469
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

  3. XM_017359015.2 → XP_017214504.1  glutathione reductase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z2M1, E7FGA5
    Related
    ENSDARP00000108870.1, ENSDART00000127479.3
    Conserved Domains (3) summary
    TIGR01421
    Location:56 → 500
    gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
    pfam00070
    Location:208 → 284
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:390 → 498
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394925.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    118307..139720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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