dnmt3ab DNA (cytosine-5-)-methyltransferase 3 alpha b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnmt3abprovided by ZNC
Official Full Name: DNA (cytosine-5-)-methyltransferase 3 alpha bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050314-3
See related: Ensembl:ENSDARG00000015566 AllianceGenome:ZFIN:ZDB-GENE-050314-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dnmt6; dnmt3a1
Summary: Predicted to enable DNA (cytosine-5-)-methyltransferase activity; DNA binding activity; and metal ion binding activity. Predicted to act upstream of or within DNA methylation and regulation of gene expression. Predicted to be located in nucleus. Is expressed in several structures, including auditory capsule; digestive system; eye; pleuroperitoneal region; and spinal cord neural tube. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; myelodysplastic syndrome; and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (36937808..37054963, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (36993285..37107437, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA methyltransferase 3a mediates developmental thermal plasticity.
Title: DNA methyltransferase 3a mediates developmental thermal plasticity.
Duplicated dnmt3aa and dnmt3ab DNA Methyltransferase Genes Play Essential and Non-Overlapped Functions on Modulating Behavioral Control in Zebrafish.
Title: Duplicated dnmt3aa and dnmt3ab DNA Methyltransferase Genes Play Essential and Non-Overlapped Functions on Modulating Behavioral Control in Zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA (cytosine-5-)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of ATP citrate synthase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to temperature stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within swimming behavior	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA (cytosine-5)-methyltransferase 3A

Names: DNA (cytosine-5-)-methyltransferase 6

NP_001018150.1

EC 2.1.1.37

NP_001315096.1

EC 2.1.1.37

XP_005158902.1

EC 2.1.1.37

XP_009291474.1

EC 2.1.1.37

XP_009291475.1

EC 2.1.1.37

XP_021322836.1

EC 2.1.1.37

XP_021322837.1

EC 2.1.1.37

XP_021322838.1

EC 2.1.1.37

XP_021322839.1

EC 2.1.1.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001018140.2 → NP_001018150.1 DNA (cytosine-5)-methyltransferase 3A isoform 2

See identical proteins and their annotated locations for NP_001018150.1

Status: VALIDATED

Source sequence(s)

BX571720

UniProtKB/TrEMBL

A0A8M1N603, Q588C4

Related

ENSDARP00000108609.2, ENSDART00000126823.3

Conserved Domains (3) summary

cd05835
Location:112 → 198

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:449 → 612

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:304 → 431

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
NM_001328167.1 → NP_001315096.1 DNA (cytosine-5)-methyltransferase 3A isoform 1

Status: VALIDATED

Source sequence(s)

BX571720, CR388401

UniProtKB/TrEMBL

A0A8M1P4G9, F1R1K5

Related

ENSDARP00000126446.1, ENSDART00000151921.3

Conserved Domains (3) summary

cd05835
Location:359 → 445

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:696 → 859

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:551 → 678

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

36937808..37054963 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467162.1 → XP_021322837.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/TrEMBL

A0A8M9P050

Conserved Domains (3) summary

cd05835
Location:364 → 450

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:701 → 864

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:556 → 683

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
XM_005158845.4 → XP_005158902.1 DNA (cytosine-5)-methyltransferase 3A isoform X5

See identical proteins and their annotated locations for XP_005158902.1

UniProtKB/TrEMBL

A0A8M2B5D4, B3DGZ8

Related

ENSDARP00000151802.1, ENSDART00000187180.1

Conserved Domains (3) summary

cd05835
Location:112 → 198

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:449 → 609

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:304 → 431

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
XM_021467161.1 → XP_021322836.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/TrEMBL

A0A8M9P050

Conserved Domains (3) summary

cd05835
Location:364 → 450

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:701 → 864

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:556 → 683

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
XM_021467163.1 → XP_021322838.1 DNA (cytosine-5)-methyltransferase 3A isoform X2

UniProtKB/TrEMBL

A0A8M9P8W7

Conserved Domains (3) summary

cd05835
Location:364 → 450

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:701 → 861

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:556 → 683

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
XM_009293199.3 → XP_009291474.1 DNA (cytosine-5)-methyltransferase 3A isoform X3

UniProtKB/TrEMBL

A0A8M3B2J9

Conserved Domains (3) summary

cd05835
Location:310 → 396

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:647 → 810

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:502 → 629

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
XM_009293200.3 → XP_009291475.1 DNA (cytosine-5)-methyltransferase 3A isoform X4

See identical proteins and their annotated locations for XP_009291475.1

UniProtKB/TrEMBL

A0A8M1N603, Q588C4

Conserved Domains (3) summary

cd05835
Location:112 → 198

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:449 → 612

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11729
Location:304 → 431

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
XM_021467164.1 → XP_021322839.1 DNA (cytosine-5)-methyltransferase 3A isoform X6

UniProtKB/TrEMBL

A0A8M9PE79

Conserved Domains (2) summary

cd05835
Location:364 → 450

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

cl28890
Location:556 → 585

FYVE_like_SF; FYVE domain like superfamily