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MOB1A MOB kinase activator 1A [ Homo sapiens (human) ]

Gene ID: 55233, updated on 5-Mar-2024

Summary

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Official Symbol
MOB1Aprovided by HGNC
Official Full Name
MOB kinase activator 1Aprovided by HGNC
Primary source
HGNC:HGNC:16015
See related
Ensembl:ENSG00000114978 MIM:609281; AllianceGenome:HGNC:16015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MABKL1B; MOBKL1B
Summary
The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in lymph node (RPKM 51.6), appendix (RPKM 43.0) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
2p13.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (74152528..74178879, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (74160989..74187669, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74379655..74406006, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tet methylcytosine dioxygenase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:74374793-74375452 Neighboring gene BOLA3 divergent transcript Neighboring gene bolA family member 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:74403666-74403858 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:74405031-74405714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16047 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74415490-74416162 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74414816-74415489 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:74419240-74419966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74419967-74420694 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74425404-74425962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74433385-74433964 Neighboring gene Sharpr-MPRA regulatory region 13618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:74455229-74455729 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Neighboring gene solute carrier family 4 member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16051 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:74513902-74514036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:74516904-74517404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:74517405-74517905 Neighboring gene keratin 18 pseudogene 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression. Meng L, et al. Breast Cancer Res, 2022 Jan 4. PMID 34983617, Free PMC Article
  2. Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A. Shen J, et al. Biochem Genet, 2015 Oct. PMID 26298709
  3. Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. Wilmeth LJ, et al. Mol Biol Cell, 2010 Feb 1. PMID 19955215, Free PMC Article
  4. Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer. Kosaka Y, et al. Int J Oncol, 2007 Aug. PMID 17611689
  5. Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways. Stavridi ES, et al. Structure, 2003 Sep. PMID 12962634

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway.
    Title: CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway.
  2. Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway.
    Title: Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway.
  3. Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression.
    Title: Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression.
  4. RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer.
    Title: RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer.
  5. The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
    Title: The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
  6. validated the functional importance of an identified interaction network by characterizing a distinct novel interaction between PTPN5 and Mob1a.
    Title: A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
  7. In this study, we investigated the mechanisms behind the recruitment of MST1 and MST2 kinases to MOB1, which facilitate signal transmission in the Hippo pathway by bringing the MST1 and MST2 kinases in close vicinity to their substrates, the LATS family kinases.
    Title: MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
  8. Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A regulates its interaction with both MST kinases and LATS/NDR family kinases in vitro.
    Title: Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation.
  9. MOB1 binds differently to the NDR2 and LATS1 kinases.MOB1 interaction with Hippo and MST protein is not essential for development and tissue growth control.
    Title: Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.
  10. No relationship has been found between the MOBKL1B-NS5A interaction and hepatitis C virus replication.
    Title: Seed sequence-matched controls reveal limitations of small interfering RNA knockdown in functional and structural studies of hepatitis C virus NS5A-MOBKL1B interaction.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10788, FLJ11595

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MOB kinase activator 1A
Names
MOB1 Mps One Binder homolog A
MOB1, Mps One Binder kinase activator-like 1B
mob1 alpha
mob1 homolog 1B
mps one binder kinase activator-like 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317110.2 → NP_001304039.1  MOB kinase activator 1A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC073263, AK001650, AL122062, BC003398, BU172616, HY030276
    UniProtKB/Swiss-Prot
    Q9H8S9
    Conserved Domains (1) summary
    pfam03637
    Location:32 → 203
    Mob1_phocein; Mob1/phocein family

  2. NM_001317111.2 → NP_001304040.1  MOB kinase activator 1A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in place of the first exon compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC073263, AK001650, AL122062, BC003398, BI825399
    UniProtKB/Swiss-Prot
    Q9H8S9
    Conserved Domains (1) summary
    pfam03637
    Location:75 → 246
    Mob1_phocein; Mob1/phocein family

  3. NM_001317112.2 → NP_001304041.1  MOB kinase activator 1A isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate coding exon in the 3' end, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC073263, AK001650, AL122062, BC003398, CN426611, HY030276
    UniProtKB/TrEMBL
    D6RCK3
    Conserved Domains (1) summary
    pfam03637
    Location:33 → 138
    Mob1_phocein; Mob1/phocein family

  4. NM_018221.5 → NP_060691.2  MOB kinase activator 1A isoform 1

    See identical proteins and their annotated locations for NP_060691.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC073263, AK001650, AL122062, BC003398, HY030276
    Consensus CDS
    CCDS46340.1
    UniProtKB/Swiss-Prot
    Q53S34, Q9H3T5, Q9H8S9, Q9HAI0, Q9NVE2
    Related
    ENSP00000379364.3, ENST00000396049.5
    Conserved Domains (1) summary
    pfam03637
    Location:33 → 204
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    74152528..74178879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444894.1 → XP_047300850.1  MOB kinase activator 1A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    74160989..74187669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342778.1 → XP_054198753.1  MOB kinase activator 1A isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H8S9.4 GenPept UniProtKB/Swiss-Prot:Q9H8S9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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