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PPP2R3A protein phosphatase 2 regulatory subunit B''alpha [ Homo sapiens (human) ]

Gene ID: 5523, updated on 3-Apr-2024

Summary

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Official Symbol
PPP2R3Aprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit B''alphaprovided by HGNC
Primary source
HGNC:HGNC:9307
See related
Ensembl:ENSG00000073711 MIM:604944; AllianceGenome:HGNC:9307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR72; PR130; PPP2R3
Summary
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
Expression
Broad expression in heart (RPKM 10.6), kidney (RPKM 9.3) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
3q22.2-q22.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (135965728..136147894)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (138711499..138893700)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (135684570..135866736)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SDHB pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:135684144-135684962 Neighboring gene NADH:ubiquinone oxidoreductase subunit S6 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:135703753-135704390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:135704391-135705026 Neighboring gene Sharpr-MPRA regulatory region 9179 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:135788758-135789957 Neighboring gene DONSON pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:135876195-135876694 Neighboring gene CRIPTO pseudogene 6 Neighboring gene MSL complex subunit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:135906825-135907326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:135907961-135908462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20580 Neighboring gene hESC enhancers GRCh37_chr3:135914134-135914880 and GRCh37_chr3:135914881-135915627 Neighboring gene ribosomal protein L31 pseudogene 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation. Dzulko M, et al. Biochim Biophys Acta Rev Cancer, 2020 Dec. PMID 33068647
  2. The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A. Ahn JH, et al. Proc Natl Acad Sci U S A, 2007 Jun 5. PMID 17535922, Free PMC Article
  3. Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A. Janssens V, et al. J Biol Chem, 2003 Mar 21. PMID 12524438
  4. The formation and activity of PP2A holoenzymes do not depend on the isoform of the catalytic subunit. Zhou J, et al. J Biol Chem, 2003 Mar 7. PMID 12506124
  5. Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma. Jiao N, et al. Biomed Environ Sci, 2022 Jul 20. PMID 35945177

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of Protein Phosphatase 2 Regulatory Subunit B""Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma.
    Title: Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma.
  2. A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies.
    Title: A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies.
  3. The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation.
    Title: The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation.
  4. [Functional Hypermethylation of ALDH1L1, PLCL2, and PPP2R3A in Colon Cancer].
    Title: [Functional Hypermethylation of ALDH1L1, PLCL2, and PPP2R3A in Colon Cancer].
  5. HDAC1 and HDAC2 suppress the expression of PPP2R3A/PR130, a regulatory subunit of the trimeric serine/threonine phosphatase 2 (PP2A).
    Title: HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.
  6. this study shows the importance of PP2A complexes with the LIM domains of lipoma-preferred partner in cell adhesion and migration dynamics
    Title: PP2A binds to the LIM domains of lipoma-preferred partner through its PR130/B″ subunit to regulate cell adhesion and migration.
  7. PP2A can be targeted in a calcium-regulated manner to Cdc6 via the PR70 subunit, where it plays a role in regulating protein phosphorylation and stability.
    Title: Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit.
  8. The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.
    Title: The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.
  9. two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A demonstrating the ability or calcium ions to interact with and regulate PP2A
    Title: Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A.
  10. PR72 interacts physically and functionally with Naked cuticle. PR72, like Naked cuticle, acts as a negative regulator of the classical Wnt signaling cascade.
    Title: PR72, a novel regulator of Wnt signaling required for Naked cuticle function.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of the Protein C anticoagulant pathway.
EBI GWAS Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in somite development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein phosphatase type 2A complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Names
PR130/B''alpha1 subunit
PR72/B''alpha2 subuit
protein phosphatase 2, regulatory subunit B'', alpha
serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
NP_001177376.1
NP_002709.2
NP_871626.1
XP_006713749.1
XP_011511258.1
XP_016862276.1
XP_047304465.1
XP_047304466.1
XP_054203133.1
XP_054203134.1
XP_054203135.1
XP_054203136.1
XP_054203137.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029234.1 RefSeqGene

    Range
    5056..187222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190447.2 → NP_001177376.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 3

    See identical proteins and their annotated locations for NP_001177376.1

    Status: REVIEWED

    Description
    Transcript Variant: variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK298059, AL389975, DB223168, DB378665
    Consensus CDS
    CCDS54642.1
    UniProtKB/Swiss-Prot
    Q06190
    Related
    ENSP00000419344.1, ENST00000490467.5
    Conserved Domains (1) summary
    pfam13499
    Location:167 → 265
    EF-hand_7; EF-hand domain pair

  2. NM_002718.5 → NP_002709.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_002709.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as isoform beta or isoform PR130.
    Source sequence(s)
    AK293012, AL389975, DB378665
    Consensus CDS
    CCDS3087.1
    UniProtKB/Swiss-Prot
    A8KAE7, B4DNU1, B7ZAE3, Q06189, Q06190, Q9NPQ5
    UniProtKB/TrEMBL
    B2RAL3, Q6P0N9
    Related
    ENSP00000264977.3, ENST00000264977.8
    Conserved Domains (1) summary
    pfam13499
    Location:903 → 1001
    EF-hand_7; EF-hand domain pair

  3. NM_181897.3 → NP_871626.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_871626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (2), also known as isoform alpha or isoform PR72, contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC072039, AK316258, AL389975, DB378665
    Consensus CDS
    CCDS3088.1
    UniProtKB/TrEMBL
    B4DS28
    Related
    ENSP00000334748.2, ENST00000334546.6
    Conserved Domains (1) summary
    pfam13499
    Location:282 → 380
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    135965728..136147894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006787.3 → XP_016862276.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

    UniProtKB/TrEMBL
    B2RAL3, Q6P0N9

  2. XM_006713686.5 → XP_006713749.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006713749.1

    UniProtKB/Swiss-Prot
    A8KAE7, B4DNU1, B7ZAE3, Q06189, Q06190, Q9NPQ5
    UniProtKB/TrEMBL
    B2RAL3, Q6P0N9
    Conserved Domains (1) summary
    pfam13499
    Location:903 → 1001
    EF-hand_7; EF-hand domain pair

  3. XM_047448510.1 → XP_047304466.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

  4. XM_011512956.4 → XP_011511258.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_011511258.1

    UniProtKB/Swiss-Prot
    A8KAE7, B4DNU1, B7ZAE3, Q06189, Q06190, Q9NPQ5
    UniProtKB/TrEMBL
    B2RAL3, Q6P0N9
    Conserved Domains (1) summary
    pfam13499
    Location:903 → 1001
    EF-hand_7; EF-hand domain pair

  5. XM_047448509.1 → XP_047304465.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

RNA

  1. XR_001740196.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    138711499..138893700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347160.1 → XP_054203135.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

  2. XM_054347158.1 → XP_054203133.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1

  3. XM_054347159.1 → XP_054203134.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1

  4. XM_054347162.1 → XP_054203137.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

  5. XM_054347161.1 → XP_054203136.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

RNA

  1. XR_008486746.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06190.1 GenPept UniProtKB/Swiss-Prot:Q06190

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