twist1b twist family bHLH transcription factor 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: twist1bprovided by ZNC
Official Full Name: twist family bHLH transcription factor 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-357
See related: Ensembl:ENSDARG00000076010 AllianceGenome:ZFIN:ZDB-GENE-050417-357
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Twist1a; zgc:110208
Summary: Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including circulatory system development; pharyngeal system development; and regulation of bone mineralization. Predicted to be located in nucleus. Is expressed in several structures, including brain; cardiovascular system; cranial vault; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Orthologous to human TWIST1 (twist family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (19732539..19735040)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (19926724..19928437)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular valve morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pharyngeal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: twist-related protein 1; twist-related protein 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017820.1 → NP_001017820.1 twist-related protein 1b

See identical proteins and their annotated locations for NP_001017820.1

Status: PROVISIONAL

Source sequence(s)

BC092796

UniProtKB/TrEMBL

A0A8N7XJ15, A6N870, E7F9A7, Q568M7

Related

ENSDARP00000052926.6, ENSDART00000052927.7

Conserved Domains (1) summary

pfam00010
Location:76 → 126

HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

19732539..19735040

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021466686.1 → XP_021322361.1 twist-related protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M9PJG9

Related

ENSDARP00000124909.2, ENSDART00000149901.3

Conserved Domains (1) summary

pfam00010
Location:76 → 126

HLH; Helix-loop-helix DNA-binding domain
XM_009292236.3 → XP_009290511.1 twist-related protein 1 isoform X2

UniProtKB/TrEMBL

A0A8M3ATB8

Conserved Domains (1) summary

pfam00010
Location:76 → 121

HLH; Helix-loop-helix DNA-binding domain