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gad2 glutamate decarboxylase 2 [ Danio rerio (zebrafish) ]

Gene ID: 550403, updated on 11-Apr-2024

Summary

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Official Symbol
gad2provided by ZNC
Official Full Name
glutamate decarboxylase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030909-9
See related
Ensembl:ENSDARG00000015537 AllianceGenome:ZFIN:ZDB-GENE-030909-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
GAD65; zgc:112198
Summary
Predicted to enable glutamate decarboxylase activity and pyridoxal phosphate binding activity. Acts upstream of or within gamma-aminobutyric acid biosynthetic process and neurotransmitter biosynthetic process. Is expressed in central nervous system; eye; and neurons. Human ortholog(s) of this gene implicated in gestational diabetes; schizophrenia; and type 1 diabetes mellitus. Orthologous to human GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (6133145..6158933, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (6103816..6129604, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene si:ch211-37e10.1 Neighboring gene NELL (neural EGFL like) family member 3 Neighboring gene myosin IIIA Neighboring gene uncharacterized LOC108181524

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular characterization and comparative localization of the mRNAs encoding two glutamic acid decarboxylases (GAD65 and GAD67) in the brain of the African lungfish, Protopterus annectens. Trabucchi M, et al. J Comp Neurol, 2008 Feb 20. PMID 18085593
  2. Cloning and immunolocalization of a rat pancreatic Na(+) bicarbonate cotransporter. Thévenod F, et al. Biochem Biophys Res Commun, 1999 Oct 14. PMID 10527880
  3. Sequence and expression of glutamic acid decarboxylase isoforms in the developing zebrafish. Martin SC, et al. J Comp Neurol, 1998 Jun 29. PMID 9634146
  4. Hypothalamic Galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop. Corradi L, et al. Curr Biol, 2022 Apr 11. PMID 35219430
  5. Engrailed-1 expression marks a primitive class of inhibitory spinal interneuron. Higashijima S, et al. J Neurosci, 2004 Jun 23. PMID 15215305, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GAD65 mRNA was found in the periaqueductal gray.
    Title: Molecular characterization and comparative localization of the mRNAs encoding two glutamic acid decarboxylases (GAD65 and GAD67) in the brain of the African lungfish, Protopterus annectens.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid biosynthetic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glutamate decarboxylation to succinate IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate decarboxylase 2
NP_001017708.2
XP_021325843.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017708.2 → NP_001017708.2  glutamate decarboxylase 2

    Status: PROVISIONAL

    Source sequence(s)
    BX530066, CR855137
    UniProtKB/TrEMBL
    A0A8M1N545, F1R9E8
    Related
    ENSDARP00000010443.8, ENSDART00000021609.10
    Conserved Domains (2) summary
    pfam00282
    Location:136 → 506
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    cl21457
    Location:511 → 561
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    6133145..6158933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470168.1 → XP_021325843.1  glutamate decarboxylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PG03
    Conserved Domains (2) summary
    pfam00282
    Location:31 → 401
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    cl25416
    Location:406 → 456
    DRE_TIM_metallolyase; DRE-TIM metallolyase superfamily
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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