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nsdhl NAD(P) dependent steroid dehydrogenase-like [ Danio rerio (zebrafish) ]

Gene ID: 550369, updated on 27-Mar-2024

Summary

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Official Symbol
nsdhlprovided by ZNC
Official Full Name
NAD(P) dependent steroid dehydrogenase-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-163
See related
Ensembl:ENSDARG00000099315 AllianceGenome:ZFIN:ZDB-GENE-050417-163
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:112474
Summary
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Acts upstream of or within response to yeast. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to human NSDHL (NAD(P) dependent steroid dehydrogenase-like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (14646717..14659083, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (14341154..14353520, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene RAB9B, member RAS oncogene family Neighboring gene fucosyltransferase 11 (alpha (1,3) fucosyltransferase) Neighboring gene zinc finger protein 185 with LIM domain Neighboring gene centrin, EF-hand protein, 2 Neighboring gene germ cell nuclear acidic peptidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regeneration Rosetta: An Interactive Web Application To Explore Regeneration-Associated Gene Expression and Chromatin Accessibility. Rau A, et al. G3 (Bethesda), 2019 Dec 3. PMID 31575636, Free PMC Article
  2. Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Weger M, et al. J Neuroendocrinol, 2018 Apr. PMID 29486070
  3. Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Li RF, et al. Biomedicines, 2022 May 27. PMID 35740282, Free PMC Article
  4. MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. Weger M, et al. Elife, 2020 Sep 24. PMID 32969791, Free PMC Article
  5. Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. Wang YC, et al. BMC Syst Biol, 2013 Aug 16. PMID 23947337, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
NP_001017674.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017674.1 → NP_001017674.1  sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

    See identical proteins and their annotated locations for NP_001017674.1

    Status: PROVISIONAL

    Source sequence(s)
    BC093332
    UniProtKB/TrEMBL
    Q566U2
    Related
    ENSDARP00000140493.1, ENSDART00000172241.2
    Conserved Domains (2) summary
    pfam01073
    Location:14 → 260
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
    cl21454
    Location:11 → 338
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    14646717..14659083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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