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hrasa HRas proto-oncogene, GTPase a [ Danio rerio (zebrafish) ]

Gene ID: 550286, updated on 25-Apr-2024

Summary

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Official Symbol
hrasaprovided by ZNC
Official Full Name
HRas proto-oncogene, GTPase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-95
See related
Ensembl:ENSDARG00000098497 AllianceGenome:ZFIN:ZDB-GENE-050417-95
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hras; sb:eu826; zgc:110250
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in basal plate midbrain region; nervous system; and trigeminal placode. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 25
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (25395590..25434376, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (25300512..25339298, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909866 Neighboring gene uncharacterized LOC110438393 Neighboring gene zgc:123278 Neighboring gene leucine rich repeat containing 56 Neighboring gene Ras association domain family member 7a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Lam IK, et al. Mol Nutr Food Res, 2012 Jun. PMID 22707269
  2. Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish. Santoriello C, et al. PLoS One, 2010 Dec 10. PMID 21170325, Free PMC Article
  3. Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish. Rosello M, et al. Elife, 2021 Feb 12. PMID 33576334, Free PMC Article
  4. The Kinase Activity-deficient Isoform of the Protein Araf Antagonizes Ras/Mitogen-activated Protein Kinase (Ras/MAPK) Signaling in the Zebrafish Embryo. Xiong C, et al. J Biol Chem, 2015 Oct 16. PMID 26306042, Free PMC Article
  5. Identification of multipath genes differentially expressed in pathway-targeted microarrays in zebrafish infected and surviving spring viremia carp virus (SVCV) suggest preventive drug candidates. Encinas P, et al. PLoS One, 2013. PMID 24069208, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish
    Title: Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
HRas proto-oncogene, GTPase a
Names
v-Ha-ras Harvey rat sarcoma viral oncogene homolog a
xRAS1
NP_001017623.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017623.1 → NP_001017623.1  HRas proto-oncogene, GTPase a

    See identical proteins and their annotated locations for NP_001017623.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092826
    UniProtKB/TrEMBL
    Q568K0
    Related
    ENSDARP00000142010.1, ENSDART00000171589.2
    Conserved Domains (2) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    smart00173
    Location:16 → 166
    RAS; Ras subfamily of RAS small GTPases

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    25395590..25434376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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