PPM1G protein phosphatase, Mg2+/Mn2+ dependent 1G [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPM1Gprovided by HGNC
Official Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1Gprovided by HGNC
Primary source: HGNC:HGNC:9278
See related: Ensembl:ENSG00000115241 MIM:605119; AllianceGenome:HGNC:9278
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PP2CG; PPP2CG; PP2CGAMMA
Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Expression: Broad expression in testis (RPKM 133.0), lymph node (RPKM 28.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p23.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (27381199..27409591, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (27423594..27451985, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (27604066..27632458, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prognostic and immunological potential of PPM1G in lung adenocarcinoma.
Title: Prognostic and immunological potential of PPM1G in lung adenocarcinoma.
PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6.
Title: PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6.
High expression of PPM1G is associated with the progression and poor prognosis of hepatocellular carcinoma.
Title: High expression of PPM1G is associated with the progression and poor prognosis of hepatocellular carcinoma.
PPM1G promotes the progression of hepatocellular carcinoma via phosphorylation regulation of alternative splicing protein SRSF3.
Title: PPM1G promotes the progression of hepatocellular carcinoma via phosphorylation regulation of alternative splicing protein SRSF3.
Proteomics reveals protein phosphatase 1gamma as a biomarker associated with Hippo signal pathway in glioma.
Title: Proteomics reveals protein phosphatase 1γ as a biomarker associated with Hippo signal pathway in glioma.
Prognostic and immunological potential of PPM1G in hepatocellular carcinoma.
Title: Prognostic and immunological potential of PPM1G in hepatocellular carcinoma.
The ARF tumor suppressor targets PPM1G/PP2Cgamma to counteract NF-kappaB transcription tuning cell survival and the inflammatory response.
Title: The ARF tumor suppressor targets PPM1G/PP2Cγ to counteract NF-κB transcription tuning cell survival and the inflammatory response.
Association of PPM1G methylation with risk-taking in alcohol use disorder.
Title: Association of PPM1G methylation with risk-taking in alcohol use disorder.
a new holoenzyme with PPM1G-B56delta as integral components, in which the regulatory subunit provides accessibility to distinct substrates for the phosphatase by defining its cellular localization, is reported.
Title: PPM1G forms a PPP-type phosphatase holoenzyme with B56δ that maintains adherens junction integrity.
PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP.
Title: PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Loss of PPM1G expression by siRNA results in downregulation of HIV-1 Gag production in cells and CA in virions, indicating that HIV-1 transcription is regulated by PPM1G	PubMed
Tat	tat	HIV-1 Tat binds PPM1G and the activation domain (residues 1-48) of Tat and the acidic domain of PPM1G are required to the binding. Tat mutant K41A abolishes the binding	PubMed
	tat	HIV-1 Tat recruits PPM1G phosphatase protein to dephosphorylate the T loop of CDK9 and release P-TEFb from the 7SK snRNP complex	PubMed
	tat	HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription	PubMed
	tat	HIV-1 Tat is identified to have a physical interaction with protein phosphatase, Mg2+/Mn2+ dependent, 1G (PPM1G) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
capsid	gag	Loss of PPM1G expression by siRNA results in downregulation of HIV-1 Gag production in cells and CA in virions, indicating that HIV-1 transcription is regulated by PPM1G	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppm1g (e-PCR), detects polymorphism
- UniSTS:143109

D11S2921 (e-PCR)
- UniSTS:152074

G54114 (e-PCR)
- UniSTS:109351

D8S2279 (e-PCR)
- UniSTS:473907

NoName (e-PCR)
- UniSTS:109369

D15S1477 (e-PCR)
- UniSTS:474482

PPM1G_7857 (e-PCR)
- UniSTS:471724

RH48963 (e-PCR)
- UniSTS:70134

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in peptidyl-threonine dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: protein phosphatase 1G

Names: PP2C-gamma; protein phosphatase 1C; protein phosphatase magnesium-dependent 1 gamma

NP_817092.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177983.3 → NP_817092.1 protein phosphatase 1G

See identical proteins and their annotated locations for NP_817092.1

Status: REVIEWED

Source sequence(s)

BC000057, DA520893

Consensus CDS

CCDS1752.1

UniProtKB/Swiss-Prot

O15355

UniProtKB/TrEMBL

B2R665, Q6IAU5

Related

ENSP00000342778.4, ENST00000344034.5

Conserved Domains (2) summary

smart00332
Location:25 → 110

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

cd00143
Location:324 → 505

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...