nr1h3 nuclear receptor subfamily 1, group H, member 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nr1h3provided by ZNC
Official Full Name: nuclear receptor subfamily 1, group H, member 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-050410-7
See related: Ensembl:ENSDARG00000098439 AllianceGenome:ZFIN:ZDB-GENE-050410-7
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7141239; wu:fd59b01; zgc:113339; zgc:158542
Summary: Enables nuclear receptor activity. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; lipid homeostasis; and regulation of intestinal lipid absorption. Predicted to be located in nucleus. Is expressed in several structures, including brain; digestive system; eye; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to several human genes including NR1H3 (nuclear receptor subfamily 1 group H member 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 7

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (34415615..34448076, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (34144465..34177430, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intestinal nr1h3 activation delays transport of absorbed neutral lipids, with accumulation of neutral lipids in enterocyte cytoplasmic droplets.
Title: Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids.
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
Title: Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis.
Results describe transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish.
Title: Transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables proline dipeptidase activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within lipid homeostasis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of intestinal lipid absorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: oxysterols receptor LXR-alpha

Names: LXRalpha; liver X receptor; lxr

NP_001017545.2

EC 3.4.13.9

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017545.3 → NP_001017545.2 oxysterols receptor LXR-alpha

Status: VALIDATED

Source sequence(s)

CU075709, FO704901

UniProtKB/TrEMBL

A0A0R4IVP0, A0A8M1N4V7

Related

ENSDARP00000139970.2, ENSDART00000170935.3

Conserved Domains (2) summary

cd06954
Location:204 → 439

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cd07160
Location:74 → 174

NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers