PPARA peroxisome proliferator activated receptor alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPARAprovided by HGNC
Official Full Name: peroxisome proliferator activated receptor alphaprovided by HGNC
Primary source: HGNC:HGNC:9232
See related: Ensembl:ENSG00000186951 MIM:170998; AllianceGenome:HGNC:9232
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PPAR; NR1C1; hPPAR; PPARalpha; PPAR-alpha
Summary: Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in kidney (RPKM 12.0), heart (RPKM 8.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.31

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (46150526..46243756)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (46635225..46728457)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (46546429..46639653)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARalpha.
Title: The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα.
Pan PPAR agonist stimulation of induced MSCs produces extracellular vesicles with enhanced renoprotective effect for acute kidney injury.
Title: Pan PPAR agonist stimulation of induced MSCs produces extracellular vesicles with enhanced renoprotective effect for acute kidney injury.
MiR-455-3p mediates PPARalpha through UBN2 to promote apoptosis and autophagy in acute myeloid leukemia cells.
Title: MiR-455-3p mediates PPARα through UBN2 to promote apoptosis and autophagy in acute myeloid leukemia cells.
PPARA and IL6: exploring associations with athletic performance and genotype polymorphism.
Title: PPARA and IL6: exploring associations with athletic performance and genotype polymorphism.
Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines.
Title: Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines.
Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.
Title: Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.
[Preliminary study of PPARA regulate the ferroptosis of hepatocellular carcinoma to prevent disease deterioration].
Title: [Preliminary study of PPARA regulate the ferroptosis of hepatocellular carcinoma to prevent disease deterioration].
miR-4433a-3p promotes granulosa cell apoptosis by targeting peroxisome proliferator-activated receptor alpha and inducing immune cell infiltration in polycystic ovarian syndrome.
Title: miR-4433a-3p promotes granulosa cell apoptosis by targeting peroxisome proliferator-activated receptor alpha and inducing immune cell infiltration in polycystic ovarian syndrome.
The emerging role of PPAR-alpha in breast cancer.
Title: The emerging role of PPAR-alpha in breast cancer.
Therapeutic roles of PPARalpha activation in ocular ischemic diseases.
Title: Therapeutic roles of PPARα activation in ocular ischemic diseases.

Submit: New GeneRIF Correction See all GeneRIFs (480)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	PPARalpha and PPARgamma over-expression prevent Tat-induced binding activity and transactivation of nuclear factor-kappaB	PubMed
	tat	Over-expression of PPARalpha or PPARgamma attenuates Tat-induced up-regulation of inflammatory mediators, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, CCL2, and E-selectin	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A009O07 (e-PCR)
- UniSTS:20995

RH27889 (e-PCR)
- UniSTS:87061

G32699 (e-PCR)
- UniSTS:117281

SHGC-32144 (e-PCR)
- UniSTS:80933

D8S2279 (e-PCR)
- UniSTS:473907

WI-11293 (e-PCR)
- UniSTS:29003

D22S1586 (e-PCR)
- UniSTS:473697

Cda02e06 (e-PCR)
- UniSTS:91036

RH45682 (e-PCR)
- UniSTS:34755

WI-17171 (e-PCR)
- UniSTS:57045

D22S1562 (e-PCR)
- UniSTS:8927

G20431 (e-PCR)
- UniSTS:20447

RH80031 (e-PCR)
- UniSTS:91103

A005R09 (e-PCR)
- UniSTS:20448

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables MDM2/MDM4 family protein binding	IEA Inferred from Electronic Annotation more info
enables NFAT protein binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables mitogen-activated protein kinase kinase kinase binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear steroid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in behavioral response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to fructose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in enamel mineralization	IEA Inferred from Electronic Annotation more info
involved_in epidermis development	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cholesterol storage	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycolytic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of hepatocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of leukocyte cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of macrophage derived foam cell differentiation	IC Inferred by Curator more info	PubMed
involved_in negative regulation of macrophage derived foam cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sequestering of triglyceride	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in nitric oxide metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fatty acid beta-oxidation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transformation of host cell by virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular ketone metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of fatty acid transport	TAS Traceable Author Statement more info	PubMed
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in steroid hormone mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: peroxisome proliferator-activated receptor alpha

Names: nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012204.2 RefSeqGene

Range

4993..98222

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001001928.4 → NP_001001928.1 peroxisome proliferator-activated receptor alpha isoform 1

See identical proteins and their annotated locations for NP_001001928.1

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Consensus CDS

CCDS33669.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001001929.3 → NP_001001929.1 peroxisome proliferator-activated receptor alpha isoform 1

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Consensus CDS

CCDS33669.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001362872.2 → NP_001349801.1 peroxisome proliferator-activated receptor alpha isoform 1

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Consensus CDS

CCDS33669.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001362873.3 → NP_001349802.1 peroxisome proliferator-activated receptor alpha isoform 1

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Consensus CDS

CCDS33669.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001393941.1 → NP_001380870.1 peroxisome proliferator-activated receptor alpha isoform 1

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Consensus CDS

CCDS33669.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001393942.1 → NP_001380871.1 peroxisome proliferator-activated receptor alpha isoform 1

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Consensus CDS

CCDS33669.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001393943.1 → NP_001380872.1 peroxisome proliferator-activated receptor alpha isoform 1

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Consensus CDS

CCDS33669.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001393944.1 → NP_001380873.1 peroxisome proliferator-activated receptor alpha isoform 1

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Consensus CDS

CCDS33669.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001393945.1 → NP_001380874.1 peroxisome proliferator-activated receptor alpha isoform 1

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Consensus CDS

CCDS33669.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001393946.1 → NP_001380875.1 peroxisome proliferator-activated receptor alpha isoform 2

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Conserved Domains (2) summary

cd06932
Location:201 → 462

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001393947.1 → NP_001380876.1 peroxisome proliferator-activated receptor alpha isoform 3

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Conserved Domains (2) summary

cl02596
Location:101 → 169

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:170 → 250

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_005036.6 → NP_005027.2 peroxisome proliferator-activated receptor alpha isoform 1

See identical proteins and their annotated locations for NP_005027.2

Status: REVIEWED

Source sequence(s)

AL078611, FP325332

Consensus CDS

CCDS33669.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Related

ENSP00000385523.1, ENST00000407236.6

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000022.11 Reference GRCh38.p14 Primary Assembly

Range

46150526..46243756

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047441420.1 → XP_047297376.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_047441421.1 → XP_047297377.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_047441423.1 → XP_047297379.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_047441424.1 → XP_047297380.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_047441422.1 → XP_047297378.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_011530240.3 → XP_011528542.1 peroxisome proliferator-activated receptor alpha isoform X1

See identical proteins and their annotated locations for XP_011528542.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_011530239.3 → XP_011528541.1 peroxisome proliferator-activated receptor alpha isoform X1

See identical proteins and their annotated locations for XP_011528541.1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_047441428.1 → XP_047297384.1 peroxisome proliferator-activated receptor alpha isoform X4
XM_047441430.1 → XP_047297386.1 peroxisome proliferator-activated receptor alpha isoform X6

Conserved Domains (1) summary

cl02596
Location:101 → 170

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
XM_047441429.1 → XP_047297385.1 peroxisome proliferator-activated receptor alpha isoform X5
XM_047441425.1 → XP_047297381.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_047441426.1 → XP_047297382.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4

Related

ENSP00000385246.1, ENST00000402126.1
XM_017028839.2 → XP_016884328.1 peroxisome proliferator-activated receptor alpha isoform X2

Conserved Domains (1) summary

cd06932
Location:67 → 333

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
XM_047441427.1 → XP_047297383.1 peroxisome proliferator-activated receptor alpha isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060946.1 Alternate T2T-CHM13v2.0

Range

46635225..46728457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054325739.1 → XP_054181714.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_054325740.1 → XP_054181715.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_054325742.1 → XP_054181717.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_054325743.1 → XP_054181718.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_054325741.1 → XP_054181716.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_054325737.1 → XP_054181712.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_054325738.1 → XP_054181713.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_054325748.1 → XP_054181723.1 peroxisome proliferator-activated receptor alpha isoform X4
XM_054325750.1 → XP_054181725.1 peroxisome proliferator-activated receptor alpha isoform X6
XM_054325749.1 → XP_054181724.1 peroxisome proliferator-activated receptor alpha isoform X5
XM_054325744.1 → XP_054181719.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_054325745.1 → XP_054181720.1 peroxisome proliferator-activated receptor alpha isoform X1

UniProtKB/Swiss-Prot

B0G0X3, Q07869, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1

UniProtKB/TrEMBL

F1D8S4
XM_054325746.1 → XP_054181721.1 peroxisome proliferator-activated receptor alpha isoform X2
XM_054325747.1 → XP_054181722.1 peroxisome proliferator-activated receptor alpha isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001001930.2: Suppressed sequence

Description

NM_001001930.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
NM_032644.3: Suppressed sequence

Description

NM_032644.3: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.