ptges prostaglandin E synthase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptgesprovided by ZNC
Official Full Name: prostaglandin E synthaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050407-2
See related: Ensembl:ENSDARG00000020136 AllianceGenome:ZFIN:ZDB-GENE-050407-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mpges; zgc:110052
Summary: Enables prostaglandin-E synthase activity. Acts upstream of or within cell migration involved in gastrulation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in epidermis; pectoral fin; periderm; and splanchnocranium. Orthologous to human PTGES (prostaglandin E synthase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (33339762..33347993)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (32739609..32747840)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The roles of prostaglandins and prostaglandin E synthase in the sex determination in D. rerio embryos are reported.
Title: Juvenile ovary to testis transition in zebrafish involves inhibition of ptges.
The temporal expression of ptges was investigated in the microdissected gonads, however, no differential expression that could indicate sex-specific difference between individual juvenile zebrafish was observed.
Title: Expression of prostaglandin synthases (pgds and pges) during zebrafish gonadal differentiation.
mPGES-1 is developmentally coregulated with COX-2 in vasculature.
Title: Prostaglandin E synthases in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-E synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-E synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prostaglandin E synthase

Names: microsomal prostaglandin E synthase 1

NP_001014828.1

EC 5.3.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.