Eif2s1 eukaryotic translation initiation factor 2 subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif2s1provided by RGD
Official Full Name: eukaryotic translation initiation factor 2 subunit alphaprovided by RGD
Primary source: RGD:620963
See related: Ensembl:ENSRNOG00000009432 AllianceGenome:RGD:620963
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; positive regulation of cell death; and response to manganese-induced endoplasmic reticulum stress. Located in cytoplasm; glial limiting end-foot; and nucleus. Part of eukaryotic translation initiation factor 2 complex and translation initiation ternary complex. Used to study middle cerebral artery infarction. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 815.1), Thymus (RPKM 474.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (103405880..103430549)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (97672829..97697499)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (102048372..102073041)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2alpha.
Title: C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.
TorsinA was post-transcriptionally upregulated upon acute ER stress, suggesting a role in this response. Increased basal phosphorylation of eIF2alpha in DYT1 transgenic rats was associated with abnormal response to acute ER stress. Unbiased RNA-Seq-based transcriptomic analysis of embryonic brain tissue in heterozygous and homozygous DYT1 knockin mice confirmed presence of eIF2alpha dysregulation in the DYT1 brain.
Title: Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain.
results demonstrate the sensitivity of eukaryotic initiation factor 2alpha-subunit (eIF2alpha) to stimulant exposure. Amphetamine possesses the ability to stimulate eIF2alpha phosphorylation in striatal and medial prefrontal cortex neurons in vivo in a dopamine D1 and D2 receptor-dependent manner.
Title: Amphetamine elevates phosphorylation of eukaryotic initiation factor 2α (eIF2α) in the rat forebrain via activating dopamine D1 and D2 receptors.
These results suggest a critical role of the mTOR/eIF2alpha pathway in hypoxic vascular remodeling and pulmonary arterial vascular smooth muscle cell proliferation of pulmonary hypertension.
Title: A Critical Role of the mTOR/eIF2α Pathway in Hypoxia-Induced Pulmonary Hypertension.
Dephosphorylation of eIF2alpha in the basolateral amygdala mediates memory reconsolidation of drug-paired stimuli.
Title: eIF2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory.
Data suggest maternal overweight due to high-fat diet up-regulates mTOR complex 1 (mechanistic target of rapamycin) activity and down-regulates eIF2 alpha subunit phosphorylation in placenta; such alterations contribute to placental/fetal overgrowth.
Title: Maternal overweight induced by a diet with high content of saturated fat activates placental mTOR and eIF2alpha signaling and increases fetal growth in rats.
eIF2a is hyperphosphorylated in the cortex of aged rats.
Title: ApoE ε4 is associated with eIF2α phosphorylation and impaired learning in young mice.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI292531 (e-PCR)
- UniSTS:245248

RH127504 (e-PCR)
- UniSTS:210814

Eif2a (e-PCR), detects polymorphism
- UniSTS:142978

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in PERK-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in PERK-mediated unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation in response to stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation in response to stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type B pancreatic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translational initiation in response to stress	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to kainic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to manganese-induced endoplasmic reticulum stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in stress granule assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within translation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of eukaryotic 48S preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 2 complex	ISO Inferred from Sequence Orthology more info
located_in glial limiting end-foot	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
part_of translation initiation ternary complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 2 subunit 1

Names: EIF-2A; EIF-2alpha; eIF-2-alpha; eIF2-alpha; eukaryotic translation initiation factor 2 subunit 1 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019356.1 → NP_062229.1 eukaryotic translation initiation factor 2 subunit 1

See identical proteins and their annotated locations for NP_062229.1

Status: PROVISIONAL

Source sequence(s)

J02646

UniProtKB/Swiss-Prot

P68101

UniProtKB/TrEMBL

A6HCF1

Related

ENSRNOP00000013375.2, ENSRNOT00000013375.5

Conserved Domains (1) summary

PTZ00248
Location:4 → 315

PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional