Sstr2 somatostatin receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sstr2provided by RGD
Official Full Name: somatostatin receptor 2provided by RGD
Primary source: RGD:3763
See related: Ensembl:ENSRNOG00000002793 AllianceGenome:RGD:3763
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Smstr2
Summary: Enables PDZ domain binding activity and somatostatin receptor activity. Involved in several processes, including brain development; cellular response to lipid; and peristalsis. Located in cytoplasm and plasma membrane. Orthologous to human SSTR2 (somatostatin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 48.4), Brain (RPKM 31.2) and 3 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q32.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (99163353..99170519)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (98664204..98671370)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (102136283..102143449)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Basolateral Amygdalar Somatostatin 2 Receptors in a Rat Model of Chronic Anxiety.
Title: Role of Basolateral Amygdalar Somatostatin 2 Receptors in a Rat Model of Chronic Anxiety.
Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly.
Title: Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly.
Elevated miR-16-5p induces somatostatin receptor 2 expression in neuroendocrine tumor cells.
Title: Elevated miR-16-5p induces somatostatin receptor 2 expression in neuroendocrine tumor cells.
study suggests that SSTR2 might play a critical role in the aetiopathogenesis of periodontitis
Title: Regulation of somatostatin receptor 2 by proinflammatory, microbial and obesity-related signals in periodontal cells and tissues.
suckling-induced activation of SST-SSTR2 signaling mediates, at least in part, the suppression of pulsatile LH secretion during lactation
Title: Somatostatin-Somatostatin Receptor 2 Signaling Mediates LH Pulse Suppression in Lactating Rats.
Somatostatin 2 Receptor Activation in the Rostral Ventrolateral Medulla Does Not Mediate the Decompensatory Phase of Haemorrhage.
Title: Somatostatin 2 Receptor Activation in the Rostral Ventrolateral Medulla Does Not Mediate the Decompensatory Phase of Haemorrhage.
In a chronic mild stress model, sst2 and sst4 expression increases in the habenula following imipramine treatment.
Title: Behavioral response to imipramine under chronic mild stress corresponds with increase of mRNA encoding somatostatin receptors sst2 and sst4 expression in medial habenular nucleus.
This study demonstrated that SSTR2 associated with neuronal apoptosis after intracerebral hemorrhage in adult rats.
Title: SSTR2 associated with neuronal apoptosis after intracerebral hemorrhage in adult rats.
In the jejunums of Cryptosporidium-parvum-infected rats, daily octreotide therapy decreased mRNA levels of SSTR2 on day 14 post-infection, although it increased mRNA levels of SSTR2 on day 50 post-infection. Specific SSTRs may regulate the inflammatory pathway in the rat intestinal inflammation model.
Title: Octreotide modulates the expression of somatostatin receptor subtypes in inflamed rat jejunum induced by Cryptosporidium parvum.
Chronic mild stress causes significant up-regulation of sst2 receptor in medial habenula
Title: Chronic mild stress alters the somatostatin receptors in the rat brain.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SSTR2 (e-PCR)
- UniSTS:254007

AU047965 (e-PCR)
- UniSTS:110006

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables somatostatin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables somatostatin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables somatostatin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estradiol stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in forebrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in peristalsis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in somatostatin signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatostatin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled receptor heterodimeric complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: somatostatin receptor type 2

Names: SRIF-1; SS-2-R; SS2-R; SS2R; somatostatin receptor subtype 2; somatotropin release-inhibiting factor receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019348.2 → NP_062221.1 somatostatin receptor type 2

See identical proteins and their annotated locations for NP_062221.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P30680

UniProtKB/TrEMBL

A6HKF9, A6HKG0

Related

ENSRNOP00000094133.1, ENSRNOT00000116317.1

Conserved Domains (2) summary

pfam00001
Location:60 → 312

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:54 → 327

7tm_4; Olfactory receptor