Ncor1 nuclear receptor co-repressor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54299, updated on 13-Apr-2024

Summary

Official Symbol: Ncor1provided by RGD
Official Full Name: nuclear receptor co-repressor 1provided by RGD
Primary source: RGD:3612
See related: Ensembl:ENSRNOG00000055246 AllianceGenome:RGD:3612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rxrip13
Summary: Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; nuclear receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in animal organ development; negative regulation of macromolecule metabolic process; and positive regulation of cell population proliferation. Located in nucleus and perinuclear region of cytoplasm. Used to study anxiety disorder and polycystic ovary syndrome. Biomarker of hypothyroidism and polycystic ovary syndrome. Orthologous to human NCOR1 (nuclear receptor corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 395.8), Kidney (RPKM 341.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q23

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (47498852..47641612, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (46999536..47142294, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (48629121..48772890, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NCoR negatively regulates adipogenic differentiation of mesenchymal stem cells.
Title: NCoR negatively regulates adipogenic differentiation of mesenchymal stem cells.
SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites.
Title: SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites.
PCOS rat models also showed alterations of PPARG1, NCOR1, and HDAC3 mRNA expression and methylation changes of PPARG1 and NCOR1, consistent with the results from humans.
Title: A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells.
SMRT's RD4 region can recruit factors capable of mediating nuclear export of SMRT, but whose function and/or recruitment is suppressed by HDAC3 activity
Title: In cortical neurons HDAC3 activity suppresses RD4-dependent SMRT export.
TRbeta1, NCoR-1, and the recently identified DOR/TP53INP2 are abundantly expressed and down-regulated in liver cells during APR.
Title: Changes in gene expression of DOR and other thyroid hormone receptors in rat liver during acute-phase response.
The NCoR interaction with HDAC3 modulates expression of both positively- and negatively-regulated genes by thyroid hormone in vivo.
Title: The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo.
NCoR1 expression is required to maintain IEC in a proliferative state, and PEDF is a novel transcriptional target for NCoR1 repressive action
Title: Nuclear receptor co-repressor is required to maintain proliferation of normal intestinal epithelial cells in culture and down-modulates the expression of pigment epithelium-derived factor.
the effects of colchicine (COL) and/or all-trans retinoic acid (ATRA) on expression of rexinoid receptors (RXRs) (alpha, beta, gamma), thyroid hormone receptor alpha and coregulators N-CoR, SMRT and SRC-1 mRNA in primary rat hepatocytes was investigated.
Title: The effect of all-trans retinoic acid and/or colchicine on expression of rexinoid and thyroid hormone nuclear receptors and their coregulators in primary rat hepatocytes.
NCoR, GAF, and TR interact with the CD44 negative T(3)-responsive element to enhance basal transactivation, whereas T(3) induces the remodeling of chromatin structure for repression
Title: A novel mechanism of thyroid hormone-dependent negative regulation by thyroid hormone receptor, nuclear receptor corepressor (NCoR), and GAGA-binding factor on the rat cD44 promoter.
Results suggest a sexual dimorphism in the content of progesterone receptors, estrogen receptor-beta, and SMRT, but not SRC-1, in the rat lung as well as a relation of their content to the physiological levels of progesterone and estradiol.
Title: Sexual dimorphism in the content of progesterone and estrogen receptors, and their cofactors in the lung of adult rats.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141290 (e-PCR)
- UniSTS:223286

BE115478 (e-PCR)
- UniSTS:248160

D10Chm61 (e-PCR)
- UniSTS:518278

BF405607 (e-PCR)
- UniSTS:247947

RH128597 (e-PCR)
- UniSTS:211905

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase regulator activity	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoid X receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear retinoid X receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to Thyroglobulin triiodothyronine	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within definitive erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in epidermis development	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in locomotor rhythm	ISO Inferred from Sequence Orthology more info
involved_in locomotor rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of thyroid hormone mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed
involved_in spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in spindle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thalamus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	IEA Inferred from Electronic Annotation more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	IEA Inferred from Electronic Annotation more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor corepressor 1

Names: N-CoR; N-CoR1; N-Cor/SMRT corepressor, Rip13; NCoR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271103.1 → NP_001258032.1 nuclear receptor corepressor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K2B4, A0A8I5ZV51

Related

ENSRNOP00000072175.1, ENSRNOT00000081409.2

Conserved Domains (3) summary

smart00717
Location:439 → 484

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:441 → 483

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:151 → 238

GPS2_interact; G-protein pathway suppressor 2-interacting domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

47498852..47641612 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269692.1 → XP_063125762.1 nuclear receptor corepressor 1 isoform X16
XM_063269690.1 → XP_063125760.1 nuclear receptor corepressor 1 isoform X15
XM_039086676.1 → XP_038942604.1 nuclear receptor corepressor 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2088 → 2273

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086677.2 → XP_038942605.1 nuclear receptor corepressor 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2088 → 2273

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063269693.1 → XP_063125763.1 nuclear receptor corepressor 1 isoform X19
XM_063269691.1 → XP_063125761.1 nuclear receptor corepressor 1 isoform X16
XM_063269689.1 → XP_063125759.1 nuclear receptor corepressor 1 isoform X15
XM_039086675.1 → XP_038942603.1 nuclear receptor corepressor 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2088 → 2273

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086704.2 → XP_038942632.1 nuclear receptor corepressor 1 isoform X40

UniProtKB/TrEMBL

A6HFA1

Conserved Domains (5) summary

PRK10263
Location:1981 → 2166

PRK10263; DNA translocase FtsK; Provisional

PRK13108
Location:728 → 894

PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed

cd00167
Location:441 → 483

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:627 → 670

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:150 → 239

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_039086699.2 → XP_038942627.1 nuclear receptor corepressor 1 isoform X34

UniProtKB/TrEMBL

A6HFA1

Related

ENSRNOP00000095016.1

Conserved Domains (5) summary

PRK10263
Location:1996 → 2181

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:441 → 483

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:627 → 670

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:150 → 239

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:713 → 907

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086706.2 → XP_038942634.1 nuclear receptor corepressor 1 isoform X42

UniProtKB/TrEMBL

A6HFA1

Conserved Domains (5) summary

PRK10263
Location:1874 → 2063

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:441 → 483

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:627 → 670

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:150 → 239

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:713 → 907

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086705.2 → XP_038942633.1 nuclear receptor corepressor 1 isoform X41

UniProtKB/TrEMBL

A0A8I6APG3

Conserved Domains (5) summary

PRK10263
Location:1947 → 2132

PRK10263; DNA translocase FtsK; Provisional

PRK13108
Location:709 → 860

PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed

cd00167
Location:441 → 483

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:627 → 670

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:150 → 239

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_039086691.2 → XP_038942619.1 nuclear receptor corepressor 1 isoform X19

UniProtKB/TrEMBL

A0A8I5Y9M5

Conserved Domains (5) summary

PRK10263
Location:2067 → 2252

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:441 → 483

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:628 → 671

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:150 → 239

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:720 → 914

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086688.2 → XP_038942616.1 nuclear receptor corepressor 1 isoform X16

UniProtKB/TrEMBL

A0A8I5Y9M5

Conserved Domains (5) summary

PRK10263
Location:2075 → 2260

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:450 → 492

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:636 → 679

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:150 → 239

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:728 → 922

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086687.2 → XP_038942615.1 nuclear receptor corepressor 1 isoform X15

UniProtKB/TrEMBL

A0A8I5Y9M5

Conserved Domains (5) summary

PRK10263
Location:2076 → 2261

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:450 → 492

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:637 → 680

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:150 → 239

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:729 → 923

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086689.2 → XP_038942617.1 nuclear receptor corepressor 1 isoform X17

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2072 → 2257

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:453 → 495

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:639 → 682

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:725 → 919

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063269701.1 → XP_063125771.1 nuclear receptor corepressor 1 isoform X32
XM_039086686.2 → XP_038942614.1 nuclear receptor corepressor 1 isoform X14

UniProtKB/TrEMBL

A0A8I6AMG4

Related

ENSRNOP00000094582.1

Conserved Domains (5) summary

PRK10263
Location:2078 → 2263

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:453 → 495

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:639 → 682

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:731 → 925

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086685.2 → XP_038942613.1 nuclear receptor corepressor 1 isoform X13

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2079 → 2264

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:453 → 495

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:640 → 683

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:732 → 926

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063269699.1 → XP_063125769.1 nuclear receptor corepressor 1 isoform X30
XM_063269694.1 → XP_063125764.1 nuclear receptor corepressor 1 isoform X21
XM_063269695.1 → XP_063125765.1 nuclear receptor corepressor 1 isoform X23
XM_063269688.1 → XP_063125758.1 nuclear receptor corepressor 1 isoform X12
XM_063269696.1 → XP_063125766.1 nuclear receptor corepressor 1 isoform X25
XM_063269697.1 → XP_063125767.1 nuclear receptor corepressor 1 isoform X27
XM_039086678.2 → XP_038942606.1 nuclear receptor corepressor 1 isoform X2

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2087 → 2272

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:648 → 691

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:740 → 934

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063269702.1 → XP_063125772.1 nuclear receptor corepressor 1 isoform X33
XM_039086697.2 → XP_038942625.1 nuclear receptor corepressor 1 isoform X29

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2026 → 2211

PRK10263; DNA translocase FtsK; Provisional

PRK13108
Location:725 → 876

PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_039086693.2 → XP_038942621.1 nuclear receptor corepressor 1 isoform X20

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2066 → 2251

PRK10263; DNA translocase FtsK; Provisional

PRK13108
Location:750 → 916

PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_063269700.1 → XP_063125770.1 nuclear receptor corepressor 1 isoform X31
XM_039086684.2 → XP_038942612.1 nuclear receptor corepressor 1 isoform X10

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2082 → 2267

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:735 → 929

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063269698.1 → XP_063125768.1 nuclear receptor corepressor 1 isoform X28
XM_039086695.2 → XP_038942623.1 nuclear receptor corepressor 1 isoform X24

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2032 → 2217

PRK10263; DNA translocase FtsK; Provisional

PRK13108
Location:731 → 882

PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_039086690.2 → XP_038942618.1 nuclear receptor corepressor 1 isoform X18

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2072 → 2257

PRK10263; DNA translocase FtsK; Provisional

PRK13108
Location:756 → 922

PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_039086696.2 → XP_038942624.1 nuclear receptor corepressor 1 isoform X26

UniProtKB/TrEMBL

A0A8I6APG3

Conserved Domains (5) summary

PRK10263
Location:2030 → 2215

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063269705.1 → XP_063125775.1 nuclear receptor corepressor 1 isoform X38
XM_039086694.2 → XP_038942622.1 nuclear receptor corepressor 1 isoform X22

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2040 → 2225

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086683.2 → XP_038942611.1 nuclear receptor corepressor 1 isoform X9

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2082 → 2267

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086679.2 → XP_038942607.1 nuclear receptor corepressor 1 isoform X5

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2087 → 2272

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063269704.1 → XP_063125774.1 nuclear receptor corepressor 1 isoform X37
XM_063269703.1 → XP_063125773.1 nuclear receptor corepressor 1 isoform X36
XM_063269686.1 → XP_063125756.1 nuclear receptor corepressor 1 isoform X8
XM_063269687.1 → XP_063125757.1 nuclear receptor corepressor 1 isoform X11
XM_039086682.2 → XP_038942610.1 nuclear receptor corepressor 1 isoform X7

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2083 → 2268

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086701.2 → XP_038942629.1 nuclear receptor corepressor 1 isoform X35

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:1965 → 2154

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063269685.1 → XP_063125755.1 nuclear receptor corepressor 1 isoform X6
XM_039086680.2 → XP_038942608.1 nuclear receptor corepressor 1 isoform X3

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (4) summary

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086681.2 → XP_038942609.1 nuclear receptor corepressor 1 isoform X4

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2088 → 2273

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_039086672.2 → XP_038942600.1 nuclear receptor corepressor 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AMG4

Conserved Domains (5) summary

PRK10263
Location:2088 → 2273

PRK10263; DNA translocase FtsK; Provisional

cd00167
Location:462 → 504

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:649 → 692

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:162 → 251

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:741 → 935

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063269706.1 → XP_063125776.1 nuclear receptor corepressor 1 isoform X39

UniProtKB/TrEMBL

A0A8I5ZYC0