Nr4a2 nuclear receptor subfamily 4, group A, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nr4a2provided by RGD
Official Full Name: nuclear receptor subfamily 4, group A, member 2provided by RGD
Primary source: RGD:3202
See related: Ensembl:ENSRNOG00000005600 AllianceGenome:RGD:3202
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RNR1; Nurr1
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; negative regulation of neuron apoptotic process; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within response to inorganic substance and response to insecticide. Located in chromatin; cytoplasm; and nucleus. Biomarker of Parkinsonism and epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 23.1), Adrenal (RPKM 19.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (62098739..62115926, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (41689847..41707036, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (43111258..43128391, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

(-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1.
Title: (-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1.
[Protective effect of nuclear receptor related 1 (Nurr1) on nerves in rats with cerebral occlusion/reperfusion injury and its mechanism].
Title: [Protective effect of nuclear receptor related 1 (Nurr1) on nerves in rats with cerebral occlusion/reperfusion injury and its mechanism].
NR4A2 alleviates cardiomyocyte loss and myocardial injury in rats by transcriptionally suppressing CCR5 and inducing M2 polarization of macrophages.
Title: NR4A2 alleviates cardiomyocyte loss and myocardial injury in rats by transcriptionally suppressing CCR5 and inducing M2 polarization of macrophages.
Transplantation of Nurr1-overexpressing neural stem cells and microglia for treating parkinsonian rats.
Title: Transplantation of Nurr1-overexpressing neural stem cells and microglia for treating parkinsonian rats.
NFkappaB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.
Title: NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.
Neuronal Trans-differentiation by Transcription Factors Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in Cortical GABAergic Neurons.
Title: Neuronal Trans-differentiation by Transcription Factors Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in Cortical GABAergic Neurons.
Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
Title: Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
Early impairment of epigenetic pattern in neurodegeneration: Additional mechanisms behind pyrethroid toxicity.
Title: Early impairment of epigenetic pattern in neurodegeneration: Additional mechanisms behind pyrethroid toxicity.
Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease.
Title: Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease.
Here, we show that learning-induced expression of the CREB-regulated nuclear receptor gene Nr4a2 is selectively impaired in aged rats with memory impairments. Further, we show that Nr4a2 is regulated by histone deacetylase HDAC3 in the aged mouse hippocampus.
Title: HDAC3-Mediated Repression of the Nr4a Family Contributes to Age-Related Impairments in Long-Term Memory.

Submit: New GeneRIF Correction See all GeneRIFs (55)

General gene information

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Markers

RH138091 (e-PCR)
- UniSTS:220178

Nr4a2 (e-PCR), detects polymorphism
- UniSTS:507412

PMC109903P2 (e-PCR)
- UniSTS:270181

D3Wox30 (e-PCR)
- UniSTS:240527

Nr4a2 (e-PCR), detects polymorphism
- UniSTS:546539

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear glucocorticoid receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in adult locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in cellular response to corticotropin-releasing hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to corticotropin-releasing hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to corticotropin-releasing hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to corticotropin-releasing hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to extracellular stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to extracellular stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in central nervous system projection neuron axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in dopamine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dopamine biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dopaminergic neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in dopaminergic neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in general adaptation syndrome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within general adaptation syndrome	ISO Inferred from Sequence Orthology more info
involved_in habenula development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within habenula development	ISO Inferred from Sequence Orthology more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron maturation	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of dopamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of respiratory gaseous exchange	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of respiratory gaseous exchange	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to amphetamine	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to inorganic substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to insecticide	IDA Inferred from Direct Assay more info	PubMed
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear receptor subfamily 4 group A member 2

Names: NUR-related factor 1; RNR-1; SL-322; nuclear orphan receptor HZF-3; nuclear receptor subfamily 4 group A member 2 variant NURR1a; nuclear receptor subfamily 4 group A member 2 variant NURR1b; nuclear receptor subfamily 4 group A member 2 variant NURR1c; nuclear receptor subfamily 4 group A member 2 variant NURR2c; nuclear receptor subfamily 4 group A member 2 variant TINUR; nur related protein 1; orphan nuclear receptor NURR1; orphan receptor; regenerating liver nuclear receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019328.3 → NP_062201.2 nuclear receptor subfamily 4 group A member 2

See identical proteins and their annotated locations for NP_062201.2

Status: VALIDATED

Source sequence(s)

AW534944, CB606493, DQ092633, L08595

UniProtKB/Swiss-Prot

O35865, Q07917

UniProtKB/TrEMBL

A6JF46

Related

ENSRNOP00000072142.1, ENSRNOT00000078001.2

Conserved Domains (2) summary

cd07071
Location:361 → 598

NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:261 → 335

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

62098739..62115926 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591997.3 → XP_017447486.1 nuclear receptor subfamily 4 group A member 2 isoform X1

UniProtKB/Swiss-Prot

O35865, Q07917

UniProtKB/TrEMBL

A6JF46

Conserved Domains (2) summary

cd07071
Location:361 → 598

NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:261 → 335

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
XM_039105738.2 → XP_038961666.1 nuclear receptor subfamily 4 group A member 2 isoform X2

UniProtKB/Swiss-Prot

O35865, Q07917

UniProtKB/TrEMBL

Q3LZI5

Conserved Domains (2) summary

cd07071
Location:298 → 535

NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:198 → 272

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
XM_006234201.5 → XP_006234263.1 nuclear receptor subfamily 4 group A member 2 isoform X1

See identical proteins and their annotated locations for XP_006234263.1

UniProtKB/Swiss-Prot

O35865, Q07917

UniProtKB/TrEMBL

A6JF46

Related

ENSRNOP00000043812.3

Conserved Domains (2) summary

cd07071
Location:361 → 598

NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:261 → 335

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
XM_039105737.2 → XP_038961665.1 nuclear receptor subfamily 4 group A member 2 isoform X1

UniProtKB/Swiss-Prot

O35865, Q07917

UniProtKB/TrEMBL

A6JF46

Conserved Domains (2) summary

cd07071
Location:361 → 598

NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:261 → 335

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
XM_063284416.1 → XP_063140486.1 nuclear receptor subfamily 4 group A member 2 isoform X4

UniProtKB/TrEMBL

Q3LZI4
XM_063284415.1 → XP_063140485.1 nuclear receptor subfamily 4 group A member 2 isoform X3

UniProtKB/TrEMBL

Q3LZI7