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Mapk4 mitogen-activated protein kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54268, updated on 13-Apr-2024

Summary

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Official Symbol
Mapk4provided by RGD
Official Full Name
mitogen-activated protein kinase 4provided by RGD
Primary source
RGD:3047
See related
Ensembl:ENSRNOG00000015401 AllianceGenome:RGD:3047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable MAP kinase activity; protein dimerization activity; and protein kinase binding activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK4 (mitogen-activated protein kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 101.7), Brain (RPKM 100.5) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Mapk4 in Genome Data Viewer
Location:
18q12.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (69788058..69937524, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (67512805..67661271, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (69894692..70043634, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483051 Neighboring gene maestro Neighboring gene uncharacterized LOC120098291 Neighboring gene uncharacterized LOC102551934 Neighboring gene uncharacterized LOC108348860 Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation of a cDNA encoding the rat MAP-kinase homolog of human p63mapk. García JI, et al. Mamm Genome, 1996 Nov. PMID 8875888
  2. Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance. Xu H, et al. J Biol Chem, 2003 Aug 8. PMID 12777378
  3. Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. Kant S, et al. J Biol Chem, 2006 Nov 17. PMID 16973613
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 4
Names
ERK-4
MAP kinase 4
MAPK 4
MNK2
extracellular signal-regulated kinase 4
p63-MAPK
NP_062192.1
XP_008770388.1
XP_008770389.1
XP_017456503.1
XP_038952979.1
XP_063133592.1
XP_063133593.1
XP_063133594.1
XP_063133595.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019319.1 → NP_062192.1  mitogen-activated protein kinase 4

    See identical proteins and their annotated locations for NP_062192.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6KRD4, G3V9J9
    Conserved Domains (2) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    pfam00069
    Location:20 → 312
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    69788058..69937524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772167.4 → XP_008770389.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_008770389.1

    UniProtKB/TrEMBL
    A6KRD4, G3V9J9
    Conserved Domains (2) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    pfam00069
    Location:20 → 312
    Pkinase; Protein kinase domain

  2. XM_008772166.4 → XP_008770388.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_008770388.1

    UniProtKB/TrEMBL
    A6KRD4, G3V9J9
    Related
    ENSRNOP00000050164.3
    Conserved Domains (2) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    pfam00069
    Location:20 → 312
    Pkinase; Protein kinase domain

  3. XM_039097051.2 → XP_038952979.1  mitogen-activated protein kinase 4 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 140
    PKc_like; Protein Kinases, catalytic domain

  4. XM_063277522.1 → XP_063133592.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A6KRD4, G3V9J9

  5. XM_017601014.3 → XP_017456503.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/TrEMBL
    A6KRD4, G3V9J9
    Conserved Domains (2) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    pfam00069
    Location:20 → 312
    Pkinase; Protein kinase domain

  6. XM_063277523.1 → XP_063133593.1  mitogen-activated protein kinase 4 isoform X2

  7. XM_063277525.1 → XP_063133595.1  mitogen-activated protein kinase 4 isoform X3

  8. XM_063277524.1 → XP_063133594.1  mitogen-activated protein kinase 4 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63454.1 GenPept UniProtKB/Swiss-Prot:Q63454

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