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Maf MAF bZIP transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 54267, updated on 2-May-2024

Summary

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Symbol
Mafprovided by RGD
Full Name
MAF bZIP transcription factorprovided by RGD
Primary source
RGD:3034
See related
Ensembl:ENSRNOG00000012428 AllianceGenome:RGD:3034
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Maf2; cMaf
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Orthologous to human MAF (MAF bZIP transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 250.2), Muscle (RPKM 110.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (60259200..60622145, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (43353867..43713162, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (48179826..48200995, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene WW domain-containing oxidoreductase Neighboring gene uncharacterized LOC120098538 Neighboring gene uncharacterized LOC108348984 Neighboring gene uncharacterized LOC134483377 Neighboring gene uncharacterized LOC102547452 Neighboring gene uncharacterized LOC108348942

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel missense mutation of MAF in a Japanese family with congenital cataract by whole exome sequencing: a clinical report and review of literature. Narumi Y, et al. Am J Med Genet A, 2014 May. PMID 24664492
  2. Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA. Aguayo-Mazzucato C, et al. Diabetes, 2013 May. PMID 23305647, Free PMC Article
  3. Comprehensive mutational screening in a cohort of Danish families with hereditary congenital cataract. Hansen L, et al. Invest Ophthalmol Vis Sci, 2009 Jul. PMID 19182255
  4. Expression of c-maf and mafB genes in the skin during rat embryonic development. Ogata A, et al. Acta Histochem, 2004 Feb. PMID 15032330
  5. Pulverulent cataract with variably associated microcornea and iris coloboma in a MAF mutation family. Jamieson RV, et al. Br J Ophthalmol, 2003 Apr. PMID 12642301, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a crucial role of the transcription factor Maf in myelination and cholesterol biosynthesis and show that Maf acts downstream from Neuregulin1
    Title: Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
  2. Data suggest that triiodothyronine (T3) acts as physiological regulator of functional maturation of islet beta-cells via induction of MAFA/c-Maf; T3 has a direct receptor-ligand interaction with MAFA/c-Maf promoter.
    Title: Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA.
  3. v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog (c-maf)is differentially expressed in alpha-cells where it regulates glucagon gene expression.
    Title: Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet alpha- and beta-cells.
  4. TACI activation can upregulate c-maf expression which, in turn, controls cyclin D2, and integrin beta7 gene expression in human myeloma cell lines
    Title: TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines.
  5. Data show that FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.
    Title: FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.
  6. An Maf associated with late endosomes/lysososmes in microglia is described.
    Title: Identification of macrophage/microglia activation factor (MAF) associated with late endosomes/lysosomes in microglial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in inner ear development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inner ear development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lens development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
involved_in lens fiber cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lens fiber cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lens fiber cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in megakaryocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription factor Maf
Names
C-Maf
bZip transcription factor c-maf
proto-oncogene c-maf
transcription factor Maf-2
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019318.2 → NP_062191.2  transcription factor Maf

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    P54844
    Conserved Domains (2) summary
    cd14718
    Location:279 → 347
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86 → 119
    Maf_N; Maf N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    60259200..60622145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097958.2 → XP_038953886.1  transcription factor Maf isoform X2

    UniProtKB/Swiss-Prot
    P54844
    UniProtKB/TrEMBL
    F1LSV1
    Related
    ENSRNOP00000016577.4
    Conserved Domains (2) summary
    cd14718
    Location:279 → 347
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86 → 119
    Maf_N; Maf N-terminal region

  2. XM_039097956.2 → XP_038953884.1  transcription factor Maf isoform X1

    UniProtKB/Swiss-Prot
    P54844
    Conserved Domains (2) summary
    cd14718
    Location:279 → 347
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86 → 119
    Maf_N; Maf N-terminal region

  3. XM_039097957.2 → XP_038953885.1  transcription factor Maf isoform X2

    UniProtKB/Swiss-Prot
    P54844
    UniProtKB/TrEMBL
    F1LSV1
    Conserved Domains (2) summary
    cd14718
    Location:279 → 347
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86 → 119
    Maf_N; Maf N-terminal region

  4. XM_063278262.1 → XP_063134332.1  transcription factor Maf isoform X2

    UniProtKB/TrEMBL
    F1LSV1

  5. XM_006255696.5 → XP_006255758.1  transcription factor Maf isoform X3

    UniProtKB/Swiss-Prot
    P54844
    UniProtKB/TrEMBL
    A0A8I6B690
    Related
    ENSRNOP00000097791.1
    Conserved Domains (2) summary
    cd14718
    Location:279 → 347
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86 → 119
    Maf_N; Maf N-terminal region

RNA

  1. XR_010060025.1 RNA Sequence

  2. XR_010060024.1 RNA Sequence

  3. XR_010060023.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54844.1 GenPept UniProtKB/Swiss-Prot:P54844

Gene LinkOut

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