Cfd complement factor D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfdprovided by RGD
Official Full Name: complement factor Dprovided by RGD
Primary source: RGD:2498
See related: Ensembl:ENSRNOG00000033564 AllianceGenome:RGD:2498
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Df; Adn; EVE
Summary: Enables endopeptidase activity. Involved in Notch signaling pathway. Located in extracellular space. Used to study arthus reaction. Biomarker of obesity. Orthologous to human CFD (complement factor D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 1038.4), Adrenal (RPKM 856.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10463773..10465496, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9813148..9814871, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12634216..12635939, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adipsin is a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor
Title: Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor.

Submit: New GeneRIF Correction

General gene information

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Markers

RH94770 (e-PCR)
- UniSTS:120017

RH130951 (e-PCR)
- UniSTS:214235

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in complement activation, alternative pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within complement activation, alternative pathway	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement factor D

Names: C3 convertase activator; D component of complement (adipsin); adipsin; endogenous vascular elastase; properdin factor D

NP_001071110.1

EC 3.4.21.46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077642.1 → NP_001071110.1 complement factor D precursor

See identical proteins and their annotated locations for NP_001071110.1

Status: PROVISIONAL

Source sequence(s)

S73894

UniProtKB/Swiss-Prot

P32038

UniProtKB/TrEMBL

A6K8V5, G3V7H3

Related

ENSRNOP00000015029.1, ENSRNOT00000015029.5

Conserved Domains (1) summary

cd00190
Location:26 → 252

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...