Car2 carbonic anhydrase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Car2provided by RGD
Official Full Name: carbonic anhydrase 2provided by RGD
Primary source: RGD:2240
See related: Ensembl:ENSRNOG00000009629 AllianceGenome:RGD:2240
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ca2
Summary: Enables carbonate dehydratase activity. Involved in several processes, including positive regulation of bone resorption; positive regulation of cellular pH reduction; and positive regulation of osteoclast differentiation. Located in several cellular components, including apical part of cell; basolateral plasma membrane; and microvillus. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to human CA2 (carbonic anhydrase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 2474.6), Kidney (RPKM 1633.5) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (88462883..88478012, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (86741625..86756766, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (88097740..88112868, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Uncoupling of Carbonic Anhydrase from Na-H exchanger-1 in Experimental Colitis: A Possible Mechanistic Link with Na-H Exchanger.
Title: Uncoupling of Carbonic Anhydrase from Na-H exchanger-1 in Experimental Colitis: A Possible Mechanistic Link with Na-H Exchanger.
Myocardial carbonic anhydrase 1/2 activation is significantly elevated in diabetic ischemic cardiomyopathy.
Title: Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy.
Our results demonstrate a selective CA facilitation of acid/base transporters in the ventricular myocyte, implying a specific role for the intracellular enzyme in HCO3- transport, and hence pHi regulation in the heart.
Title: Facilitation by intracellular carbonic anhydrase of Na+ -HCO3- co-transport but not Na+ / H+ exchange activity in the mammalian ventricular myocyte.
CAII/NHE1 interaction constitutes a component of the slow force response to heart muscle stretch, which potentiates NHE1-mediated H(+) transport in the myocardium.
Title: Inhibition of carbonic anhydrase prevents the Na(+)/H(+) exchanger 1-dependent slow force response to rat myocardial stretch.
Report CAIImRNA expression was significantly decreased in ovariectomized rats exposed to pulsed electromagnetic fields.
Title: Effects of pulsed electromagnetic fields on the mRNA expression of CAII and RANK in ovariectomized rats.
CAII is expressed in rat alveolar epithelial cells and does not regulate lung alveolar fluid reabsorption during hypercapnia.
Title: Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia.
Immunohistochemical localization of proteins known to be important in HCO(3) (-) secretion was investigated in the rat common bile duct.
Title: Bicarbonate secretion by rat bile duct brush cells indicated by immunohistochemical localization of CFTR, anion exchanger AE2, Na+/HCO3 -cotransporter, carbonic anhydrase II, Na+/H+ exchangers NHE1 and NHE3, H+/K+-ATPase, and Na+/K+-ATPase.
why CAH II is cytoplasmic resident in some organs and secreted in others
Title: Molecular comparison of apocrine released and cytoplasmic resident carbonic anhydrase II.
The results indicate that there is a relationship between the fluid shear stress and the mRNA expression of CAII in polarized rat osteoclasts
Title: Effects of fluid shear stress on mRNA expression of carbonic anhydrase II in polarized rat osteoclasts.
Immunohistochemical co-expression of carbonic anhydrase II with Kv1.4 and TRPV1 in rat small-diameter trigeminal ganglion neurons
Title: Immunohistochemical co-expression of carbonic anhydrase II with Kv1.4 and TRPV1 in rat small-diameter trigeminal ganglion neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA893916 (e-PCR)
- UniSTS:250207

RH137250 (e-PCR)
- UniSTS:219338

AW533290 (e-PCR)
- UniSTS:245973

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arylesterase activity	ISO Inferred from Sequence Orthology more info
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables carbonate dehydratase activity	ISO Inferred from Sequence Orthology more info
enables cyanamide hydratase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiotensin-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbon dioxide transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within carbon dioxide transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fluid shear stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEP Inferred from Expression Pattern more info	PubMed
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in osteoclast differentiation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular pH reduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cellular pH reduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dipeptide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dipeptide transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone resorption	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cellular pH	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of chloride transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic anion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to pH	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: carbonic anhydrase 2

Names: CA-II; carbonate dehydratase II; carbonic anhydrase II; cyanamide hydratase CA2

NP_062164.1

EC 4.2.1.1

EC 4.2.1.69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019291.1 → NP_062164.1 carbonic anhydrase 2

See identical proteins and their annotated locations for NP_062164.1

Status: PROVISIONAL

Source sequence(s)

X58294

UniProtKB/Swiss-Prot

P27139

UniProtKB/TrEMBL

A0A8I6AMP9, A6IH09

Related

ENSRNOP00000013354.3, ENSRNOT00000013354.7

Conserved Domains (1) summary

cl00012
Location:1 → 259

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...