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Adcy4 adenylate cyclase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54223, updated on 11-Apr-2024

Summary

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Official Symbol
Adcy4provided by RGD
Official Full Name
adenylate cyclase 4provided by RGD
Primary source
RGD:2034
See related
Ensembl:ENSRNOG00000020401 AllianceGenome:RGD:2034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables G-protein beta/gamma-subunit complex binding activity and adenylate cyclase activity. Involved in cAMP biosynthetic process and intracellular signal transduction. Located in membrane and nucleus. Part of protein-containing complex. Orthologous to human ADCY4 (adenylate cyclase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 76.9), Lung (RPKM 53.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adcy4 in Genome Data Viewer
Location:
15p13
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33236201..33252070, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29266280..29282153, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34453917..34469779, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene leukotriene B4 receptor 2 Neighboring gene leukotriene B4 receptor Neighboring gene receptor-interacting serine-threonine kinase 3 Neighboring gene nuclear factor of activated T-cells 4 Neighboring gene NYN domain and retroviral integrase containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Distribution of adenylyl cyclases in the rat ovary by immunofluorescence microscopy. Bagavandoss P, et al. Anat Rec (Hoboken), 2012 Oct. PMID 22899545
  2. Protein kinase C alters the responsiveness of adenylyl cyclases to G protein alpha and betagamma subunits. Zimmermann G, et al. J Biol Chem, 1996 Oct 25. PMID 8900209
  3. Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Gao BN, et al. Proc Natl Acad Sci U S A, 1991 Nov 15. PMID 1946437, Free PMC Article
  4. Regulation and immunohistochemical localization of betagamma-stimulated adenylyl cyclases in mouse hippocampus. Baker LP, et al. J Neurosci, 1999 Jan 1. PMID 9870949, Free PMC Article
  5. Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein. Wang HY, et al. J Neurobiol, 2006 Oct. PMID 16967511

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93493

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables G-protein beta/gamma-subunit complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenylate cyclase type 4
Names
ATP pyrophosphate-lyase 4
adenylate cyclase type IV
adenylyl cyclase 4
NP_062158.2
XP_038949538.1
XP_038949539.1
XP_063130658.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019285.2 → NP_062158.2  adenylate cyclase type 4

    See identical proteins and their annotated locations for NP_062158.2

    Status: VALIDATED

    Source sequence(s)
    BC081813
    UniProtKB/Swiss-Prot
    P26770
    UniProtKB/TrEMBL
    A6KH53, F7EY48, Q66HK5
    Related
    ENSRNOP00000027719.4, ENSRNOT00000027719.8
    Conserved Domains (4) summary
    smart00044
    Location:219 → 422
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:861 → 1060
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:479 → 580
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:115 → 246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    33236201..33252070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093610.1 → XP_038949538.1  adenylate cyclase type 4 isoform X1

    UniProtKB/Swiss-Prot
    P26770
    Conserved Domains (3) summary
    pfam00211
    Location:729 → 928
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:1 → 114
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:347 → 448
    DUF1053; Domain of Unknown Function (DUF1053)

  2. XM_039093611.1 → XP_038949539.1  adenylate cyclase type 4 isoform X3

    Conserved Domains (3) summary
    pfam00211
    Location:547 → 746
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:165 → 266
    DUF1053; Domain of Unknown Function (DUF1053)
    cl11967
    Location:2 → 116
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

  3. XM_063274588.1 → XP_063130658.1  adenylate cyclase type 4 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26770.1 GenPept UniProtKB/Swiss-Prot:P26770

Gene LinkOut

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