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KRAS KRAS proto-oncogene, GTPase [ Bos taurus (cattle) ]

Gene ID: 541140, updated on 5-Mar-2024

Summary

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Official Symbol
KRASprovided by VGNC
Official Full Name
KRAS proto-oncogene, GTPaseprovided by VGNC
Primary source
VGNC:VGNC:30710
See related
BGD:BT12323; Ensembl:ENSBTAG00000009778
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
KRAS2; p21ras
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (84749500..84789041)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene lamin tail domain containing 1 Neighboring gene uncharacterized LOC132345327 Neighboring gene uncharacterized LOC132345328 Neighboring gene uncharacterized LOC104972526 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. S-glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells. Clavreul N, et al. FASEB J, 2006 Mar. PMID 16415107
  2. Both the C-terminal polylysine region and the farnesylation of K-RasB are important for its specific interaction with calmodulin. Wu LJ, et al. PLoS One, 2011. PMID 21750741, Free PMC Article
  3. Syntenic conservation between humans and cattle. II. Human chromosome 12. Threadgill DW, et al. Genomics, 1990 Sep. PMID 2081597
  4. Linkage relations between A2M, HOX3, INT1, KRAS2, and PAH on bovine chromosome 5. Barendse W, et al. Genomics, 1992 Sep. PMID 1385300
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the information obtained can enhance understanding of how CaM interacts with K-RasB in physiological environments.
    Title: Both the C-terminal polylysine region and the farnesylation of K-RasB are important for its specific interaction with calmodulin.
  2. Peroxynitrite increases p21ras activity in bovine aortic endothelial cells; it triggers direct S-glutathiolation of p21ras Cys-118, which increases p21ras activity and mediates downstream signaling
    Title: S-glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GDP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
GTPase KRas
Names
Kirsten rat sarcoma viral (Kras-2) oncogene homolog
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
NP_001103471.1
XP_024847870.1
XP_059742648.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110001.3 → NP_001103471.1  GTPase KRas

    See identical proteins and their annotated locations for NP_001103471.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000005
    UniProtKB/TrEMBL
    A0A3Q1LMP2
    Related
    ENSBTAP00000058153.1, ENSBTAT00000081428.1
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    84749500..84789041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024992102.2 → XP_024847870.1  GTPase KRas isoform X1

    UniProtKB/TrEMBL
    E1BMX0
    Related
    ENSBTAP00000040751.4, ENSBTAT00000043161.5
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. XM_059886665.1 → XP_059742648.1  GTPase KRas isoform X1

    UniProtKB/TrEMBL
    E1BMX0
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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