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PTK2B protein tyrosine kinase 2 beta [ Bos taurus (cattle) ]

Gene ID: 541008, updated on 3-Apr-2024

Summary

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Official Symbol
PTK2Bprovided by VGNC
Official Full Name
protein tyrosine kinase 2 betaprovided by VGNC
Primary source
VGNC:VGNC:33519
See related
BGD:BT11441; Ensembl:ENSBTAG00000005958
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PYK2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (74417327..74555613)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene stathmin 4 Neighboring gene tripartite motif containing 35 Neighboring gene uncharacterized LOC132345976 Neighboring gene cholinergic receptor nicotinic alpha 2 subunit Neighboring gene epoxide hydrolase 2 Neighboring gene transfer RNA arginine (anticodon ACG) Neighboring gene nascent polypeptide-associated complex subunit alpha-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of tyrosine phosphorylation of PYK2 in vascular endothelial cells by lysophosphatidylcholine. Rikitake Y, et al. Am J Physiol Heart Circ Physiol, 2001 Jul. PMID 11406493
  2. Cyclic strain activates redox-sensitive proline-rich tyrosine kinase 2 (PYK2) in endothelial cells. Cheng JJ, et al. J Biol Chem, 2002 Dec 13. PMID 12368297
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]
    Title: Cyclic strain activates redox-sensitive proline-rich tyrosine kinase 2 (PYK2) in endothelial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC139227

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal complex assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein-tyrosine kinase 2-beta
Names
PTK2B protein tyrosine kinase 2 beta
NP_001095722.1
XP_059745200.1
XP_059745201.1
XP_059745202.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102252.1 → NP_001095722.1  protein-tyrosine kinase 2-beta

    See identical proteins and their annotated locations for NP_001095722.1

    Status: PROVISIONAL

    Source sequence(s)
    BC150125
    UniProtKB/TrEMBL
    A6QR59, F1N0Z0
    Related
    ENSBTAP00000059391.1, ENSBTAT00000084967.2
    Conserved Domains (6) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:425 → 679
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150 → 254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    74417327..74555613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059889218.1 → XP_059745201.1  protein-tyrosine kinase 2-beta isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LVP1

  2. XM_059889217.1 → XP_059745200.1  protein-tyrosine kinase 2-beta isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LVP1

  3. XM_059889219.1 → XP_059745202.1  protein-tyrosine kinase 2-beta isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MP24
    Related
    ENSBTAP00000073091.1, ENSBTAT00000087333.2

RNA

  1. XR_009495482.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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