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ACP5 acid phosphatase 5, tartrate resistant [ Homo sapiens (human) ]

Gene ID: 54, updated on 3-Apr-2024

Summary

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Official Symbol
ACP5provided by HGNC
Official Full Name
acid phosphatase 5, tartrate resistantprovided by HGNC
Primary source
HGNC:HGNC:124
See related
Ensembl:ENSG00000102575 MIM:171640; AllianceGenome:HGNC:124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPAP; TRAP; TRAcP; TRACP5a; TRACP5b; TrATPase
Summary
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
Expression
Broad expression in lung (RPKM 55.0), kidney (RPKM 29.2) and 16 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11574660..11578975, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11702190..11706505, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11685475..11689790, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14022 Neighboring gene calponin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11662408-11663379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14024 Neighboring gene Sharpr-MPRA regulatory region 7075 Neighboring gene elongation factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14025 Neighboring gene uncharacterized LOC124904638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11687946-11688558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11688559-11689170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14027 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11692934-11693099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14029 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 76 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10122 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11708237-11709235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10124 Neighboring gene zinc finger protein 627 Neighboring gene MPRA-validated peak3358 silencer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Spondyloenchondrodysplasia in five new patients: identification of three novel ACP5 variants with variable neurological presentations. Elhossini RM, et al. Mol Genet Genomics, 2023 May. PMID 37010587, Free PMC Article
  2. Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial. Matsuzaki K, et al. Phytother Res, 2023 Jun. PMID 36637040
  3. The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis. Gossiel F, et al. Osteoporos Int, 2022 Jun. PMID 35102444
  4. A Novel Sandwich ELISA for Tartrate-Resistant Acid Phosphatase 5a and 5b Protein Reveals that Both Isoforms are Secreted by Differentiating Osteoclasts and Correlate to the Type I Collagen Degradation Marker CTX-I In Vivo and In Vitro. Mira-Pascual L, et al. Calcif Tissue Int, 2020 Feb. PMID 31654098
  5. Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels. Patlaka C, et al. Eat Weight Disord, 2020 Oct. PMID 31531762, Free PMC Article

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spondyloenchondrodysplasia with immune dysregulation related to ACP5. A report of 4 cases.
    Title: Spondyloenchondrodysplasia with immune dysregulation related to ACP5. A report of 4 cases.
  2. Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.
    Title: Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.
  3. Spondyloenchondrodysplasia in five new patients: identification of three novel ACP5 variants with variable neurological presentations.
    Title: Spondyloenchondrodysplasia in five new patients: identification of three novel ACP5 variants with variable neurological presentations.
  4. The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis.
    Title: The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis.
  5. Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating beta-catenin signaling.
    Title: Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.
  6. microRNA-877 contributes to decreased non-small cell lung cancer cell growth via the PI3K/AKT pathway by targeting tartrate resistant acid phosphatase 5 activity.
    Title: microRNA-877 contributes to decreased non-small cell lung cancer cell growth via the PI3K/AKT pathway by targeting tartrate resistant acid phosphatase 5 activity.
  7. Expression of tartrate-resistant acid phosphatase and cathepsin K during osteoclast differentiation in developing mouse mandibles.
    Title: Expression of tartrate-resistant acid phosphatase and cathepsin K during osteoclast differentiation in developing mouse mandibles.
  8. Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels.
    Title: Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels.
  9. MMP-8, TRAP-5, and OPG Levels in GCF Diagnostic Potential to Discriminate between Healthy Patients', Mild and Severe Periodontitis Sites.
    Title: MMP-8, TRAP-5, and OPG Levels in GCF Diagnostic Potential to Discriminate between Healthy Patients', Mild and Severe Periodontitis Sites.
  10. A Novel Sandwich ELISA for Tartrate-Resistant Acid Phosphatase 5a and 5b Protein Reveals that Both Isoforms are Secreted by Differentiating Osteoclasts and Correlate to the Type I Collagen Degradation Marker CTX-I In Vivo and In Vitro.
    Title: A Novel Sandwich ELISA for Tartrate-Resistant Acid Phosphatase 5a and 5b Protein Reveals that Both Isoforms are Secreted by Differentiating Osteoclasts and Correlate to the Type I Collagen Degradation Marker CTX-I In Vivo and In Vitro.
Submit: New GeneRIF Correction See all GeneRIFs (75)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Spondyloenchondrodysplasia with immune dysregulation
MedGen: C1842763 OMIM: 607944 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of acid phosphatase 5, tartrate resistant (ACP5) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117378

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in bone morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of superoxide anion generation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cytokine IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in superoxide anion generation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
tartrate-resistant acid phosphatase type 5
Names
human purple acid phosphatase
tartrate-resistant acid ATPase
tartrate-resistant acid phosphatase 5a
tartrate-resistant acid phosphatase 5b
NP_001104504.1
NP_001104505.1
NP_001104506.1
NP_001308952.1
NP_001602.1
XP_005259995.1
XP_011526371.1
XP_047294900.1
XP_047294901.1
XP_054177203.1
XP_054177204.1
XP_054177205.1
XP_054177206.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028127.1 RefSeqGene

    Range
    6342..9327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1218

mRNA and Protein(s)

  1. NM_001111034.3 → NP_001104504.1  tartrate-resistant acid phosphatase type 5 precursor

    See identical proteins and their annotated locations for NP_001104504.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    BC025414, BP367008
    Consensus CDS
    CCDS12265.1
    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
    UniProtKB/TrEMBL
    A0A8Q3SI79
    Related
    ENSP00000512173.1, ENST00000695791.1
    Conserved Domains (1) summary
    cd07378
    Location:26 → 311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

  2. NM_001111035.3 → NP_001104505.1  tartrate-resistant acid phosphatase type 5 precursor

    See identical proteins and their annotated locations for NP_001104505.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 encode the same protein.
    Source sequence(s)
    BC025414, BC111014, BP334409
    Consensus CDS
    CCDS12265.1
    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
    UniProtKB/TrEMBL
    A0A8Q3SI79
    Related
    ENSP00000218758.4, ENST00000218758.10
    Conserved Domains (1) summary
    cd07378
    Location:26 → 311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

  3. NM_001111036.3 → NP_001104506.1  tartrate-resistant acid phosphatase type 5 precursor

    See identical proteins and their annotated locations for NP_001104506.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    BC025414, BX365007
    Consensus CDS
    CCDS12265.1
    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
    UniProtKB/TrEMBL
    A0A8Q3SI79
    Related
    ENSP00000392374.1, ENST00000412435.7
    Conserved Domains (1) summary
    cd07378
    Location:26 → 311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

  4. NM_001322023.2 → NP_001308952.1  tartrate-resistant acid phosphatase type 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC020947, BC025414, BP334409
    Consensus CDS
    CCDS12265.1
    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
    UniProtKB/TrEMBL
    A0A8Q3SI79
    Conserved Domains (1) summary
    cd07378
    Location:26 → 311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

  5. NM_001611.5 → NP_001602.1  tartrate-resistant acid phosphatase type 5 precursor

    See identical proteins and their annotated locations for NP_001602.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AK290717, BC025414
    Consensus CDS
    CCDS12265.1
    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
    UniProtKB/TrEMBL
    A0A8Q3SI79
    Related
    ENSP00000496973.1, ENST00000648477.1
    Conserved Domains (1) summary
    cd07378
    Location:26 → 311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11574660..11578975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438944.1 → XP_047294900.1  tartrate-resistant acid phosphatase type 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
    Related
    ENSP00000512191.1, ENST00000695811.1

  2. XM_011528069.3 → XP_011526371.1  tartrate-resistant acid phosphatase type 5 isoform X1

    See identical proteins and their annotated locations for XP_011526371.1

    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
    UniProtKB/TrEMBL
    A0A8Q3SI79
    Related
    ENSP00000497140.2, ENST00000649386.2
    Conserved Domains (1) summary
    cd07378
    Location:26 → 311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

  3. XM_005259938.2 → XP_005259995.1  tartrate-resistant acid phosphatase type 5 isoform X1

    See identical proteins and their annotated locations for XP_005259995.1

    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
    UniProtKB/TrEMBL
    A0A8Q3SI79
    Related
    ENSP00000468767.3, ENST00000592828.7
    Conserved Domains (1) summary
    cd07378
    Location:26 → 311
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

  4. XM_047438945.1 → XP_047294901.1  tartrate-resistant acid phosphatase type 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11702190..11706505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321229.1 → XP_054177204.1  tartrate-resistant acid phosphatase type 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7

  2. XM_054321230.1 → XP_054177205.1  tartrate-resistant acid phosphatase type 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7

  3. XM_054321228.1 → XP_054177203.1  tartrate-resistant acid phosphatase type 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7

  4. XM_054321231.1 → XP_054177206.1  tartrate-resistant acid phosphatase type 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13686.3 GenPept UniProtKB/Swiss-Prot:P13686

Gene LinkOut

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