Lpar2 lysophosphatidic acid receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpar2provided by MGI
Official Full Name: lysophosphatidic acid receptor 2provided by MGI
Primary source: MGI:MGI:1858422
See related: Ensembl:ENSMUSG00000031861 AllianceGenome:MGI:1858422
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Edg4; IPA2; LPA2
Summary: Enables PDZ domain binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Located in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; hemolymphoid system gland; and sensory organ. Orthologous to human LPAR2 (lysophosphatidic acid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 4.0), spleen adult (RPKM 3.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 33.91 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (70275215..70283752)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (69822565..69831102)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional modulation of lysophosphatidic acid type 2 G-protein coupled receptor facilitates alveolar bone formation.
Title: Functional modulation of lysophosphatidic acid type 2 G-protein coupled receptor facilitates alveolar bone formation.
LPA2 promotes neuronal differentiation and neurite formation in neocortical development.
Title: LPA(2) promotes neuronal differentiation and neurite formation in neocortical development.
Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells.
Title: Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells.
Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages.
Title: Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages.
Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.
Title: Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.
LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon.
Title: LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon.
Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2.
Title: Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2.
Pharmacologic activation of LPA2 attenuates Th2-driven allergic airway inflammation in a mouse model of asthma.
Title: Novel Inhibitory Effect of a Lysophosphatidic Acid 2 Agonist on Allergen-Driven Airway Inflammation.
These findings identify ATX and LPA2 as radiation-regulated genes that appear to play a physiological role in DNA repair.
Title: The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair.
Lysophosphatidic acid gradients induce a spatiotemporally restricted decrease in the mobility of LPA receptor 2 (LPA2) on chemotactic fibroblasts.
Title: Asymmetrical macromolecular complex formation of lysophosphatidic acid receptor 2 (LPA2) mediates gradient sensing in fibroblasts.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Edg4 (e-PCR), detects polymorphism
- UniSTS:226048

PMC134025P1 (e-PCR)
- UniSTS:270717

PMC134025P2 (e-PCR)
- UniSTS:270718

PMC134025P3 (e-PCR)
- UniSTS:270719

NoName (e-PCR)
- UniSTS:235915

Edg4 (e-PCR), detects polymorphism
- UniSTS:209583

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables lysophosphatidic acid receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with endocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lysophosphatidic acid receptor 2

Names: LPA receptor 2; LPA-2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4; lysophosphatidic acid receptor Edg-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.