Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppm1dprovided by MGI
Official Full Name: protein phosphatase 1D magnesium-dependent, delta isoformprovided by MGI
Primary source: MGI:MGI:1858214
See related: Ensembl:ENSMUSG00000020525 AllianceGenome:MGI:1858214
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wip1
Summary: Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Involved in DNA methylation and heterochromatin assembly. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; G2/M transition of mitotic cell cycle; and response to bacterium. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 45.8), cerebellum adult (RPKM 8.9) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.34 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (85202080..85237897)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (85311254..85347071)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.
Title: PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.
Wip1 regulates wound healing by affecting activities of keratinocytes and endothelial cells through ATM-p53 and mTOR signaling.
Title: Wip1 regulates wound healing by affecting activities of keratinocytes and endothelial cells through ATM-p53 and mTOR signaling.
Ppm1d truncating mutations promote the development of genotoxic stress-induced AML.
Title: Ppm1d truncating mutations promote the development of genotoxic stress-induced AML.
A Study on the Role of Wip1 in Renal Fibrosis by Modulating Macrophage Phenotype.
Title: A Study on the Role of Wip1 in Renal Fibrosis by Modulating Macrophage Phenotype.
Low WIP1 Expression Accelerates Ovarian Aging by Promoting Follicular Atresia and Primordial Follicle Activation.
Title: Low WIP1 Expression Accelerates Ovarian Aging by Promoting Follicular Atresia and Primordial Follicle Activation.
PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response.
Title: PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response.
PP2Cdelta Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Title: PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.
Title: PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.
The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice.
Title: The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice.
Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses.
Title: Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (5) 1 citation

General gene information

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Markers

AV338790 (e-PCR)
- UniSTS:185907

Ppm1d (e-PCR), detects polymorphism
- UniSTS:164928

RH135649 (e-PCR)
- UniSTS:164929

Ppm1d (e-PCR), detects polymorphism
- UniSTS:506691

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cation binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA methylation-dependent heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression, epigenetic	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein phosphatase 1D

Names: PP2C-delta; p53-induced protein phosphatase 1; protein phosphatase magnesium-dependent 1 delta

NP_058606.3

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.