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IRS1 insulin receptor substrate 1 [ Bos taurus (cattle) ]

Gene ID: 538598, updated on 5-Mar-2024

Summary

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Official Symbol
IRS1provided by VGNC
Official Full Name
insulin receptor substrate 1provided by VGNC
Primary source
VGNC:VGNC:30283
See related
BGD:BT12298; Ensembl:ENSBTAG00000021308
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (114928433..114992724, complement)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL16-like Neighboring gene uncharacterized LOC101902260 Neighboring gene microRNA mir-12053 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene rhomboid domain containing 1 Neighboring gene collagen type IV alpha 4 chain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PRL/microRNA-183/IRS1 Pathway Regulates Milk Fat Metabolism in Cow Mammary Epithelial Cells. Jiao P, et al. Genes (Basel), 2020 Feb 13. PMID 32069836, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRL/microRNA-183/IRS1 Pathway Regulates Milk Fat Metabolism in Cow Mammary Epithelial Cells.
    Title: PRL/microRNA-183/IRS1 Pathway Regulates Milk Fat Metabolism in Cow Mammary Epithelial Cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin receptor substrate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    114928433..114992724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003585773.6 → XP_003585821.1  insulin receptor substrate 1

    See identical proteins and their annotated locations for XP_003585821.1

    UniProtKB/TrEMBL
    F1MYE0
    Related
    ENSBTAP00000075009.1, ENSBTAT00000099636.1
    Conserved Domains (3) summary
    cd01204
    Location:160 → 263
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11 → 118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
    pfam00169
    Location:17 → 110
    PH; PH domain
Nucleotide Protein Strain
Heading Accession and Version

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