U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 [ Bos taurus (cattle) ]

Gene ID: 537682, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
SOS1provided by VGNC
Official Full Name
SOS Ras/Rac guanine nucleotide exchange factor 1provided by VGNC
Primary source
VGNC:VGNC:35134
See related
BGD:BT17095; Ensembl:ENSBTAG00000011643
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 11
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (21303811..21434957, complement)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346556 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene microRNA mir-2284z-2 Neighboring gene ubiquitin-ribosomal protein eS31 fusion protein-like Neighboring gene cyclin dependent kinase like 4 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene mitogen-activated protein kinase kinase kinase kinase 3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
son of sevenless homolog 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    21303811..21434957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005212709.5 → XP_005212766.1  son of sevenless homolog 1 isoform X3

    See identical proteins and their annotated locations for XP_005212766.1

    Related
    ENSBTAP00000082001.1, ENSBTAT00000132612.1
    Conserved Domains (6) summary
    smart00229
    Location:553 → 697
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:160 → 345
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:732 → 971
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:395 → 501
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00169
    Location:401 → 502
    PH; PH domain
    cl23907
    Location:83 → 133
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

  2. XM_005212708.5 → XP_005212765.1  son of sevenless homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_005212765.1

    Related
    ENSBTAP00000015471.5, ENSBTAT00000015471.5
    Conserved Domains (6) summary
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204 → 389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00169
    Location:445 → 546
    PH; PH domain
    cl23907
    Location:97 → 177
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

  3. XM_002691241.7 → XP_002691287.2  son of sevenless homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_002691287.2

    UniProtKB/TrEMBL
    F1N7C3
    Related
    ENSBTAP00000097037.1, ENSBTAT00000118195.1
    Conserved Domains (6) summary
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204 → 389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00169
    Location:445 → 546
    PH; PH domain
    cl23907
    Location:97 → 177
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.