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Nono non-POU-domain-containing, octamer binding protein [ Mus musculus (house mouse) ]

Gene ID: 53610, updated on 21-Apr-2024

Summary

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Official Symbol
Nonoprovided by MGI
Official Full Name
non-POU-domain-containing, octamer binding proteinprovided by MGI
Primary source
MGI:MGI:1855692
See related
Ensembl:ENSMUSG00000031311 AllianceGenome:MGI:1855692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nonA; NRB54; P54NRB
Summary
Enables chromatin binding activity. Involved in negative regulation of transcription, DNA-templated and regulation of circadian rhythm. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including brain; central nervous system ganglion; gut; sensory organ; and testis. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 221.3), CNS E14 (RPKM 143.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X D; X 44.14 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100473295..100492193)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101429560..101448593)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene gap junction protein, beta 1 Neighboring gene STARR-seq mESC enhancer starr_47649 Neighboring gene zinc finger, MYM-type 3 Neighboring gene STARR-positive B cell enhancer ABC_E7703 Neighboring gene integrin beta 1 binding protein 2 Neighboring gene anaphase promoting complex subunit 13 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NONO regulates B-cell development and B-cell receptor signaling. Zhang Y, et al. FASEB J, 2023 Apr. PMID 36906291
  2. NONO Regulates Cortical Neuronal Migration and Postnatal Neuronal Maturation. Liu X, et al. Neurosci Bull, 2019 Dec. PMID 31502212, Free PMC Article
  3. The RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding. Benegiamo G, et al. Cell Metab, 2018 Feb 6. PMID 29358041, Free PMC Article
  4. Cell-type specific role of the RNA-binding protein, NONO, in the DNA double-strand break response in the mouse testes. Li S, et al. DNA Repair (Amst), 2017 Mar. PMID 28209515, Free PMC Article
  5. Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency. Ma C, et al. Cell Rep, 2016 Oct 18. PMID 27760330, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation.
    Title: LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation.
  2. NONO regulates B-cell development and B-cell receptor signaling.
    Title: NONO regulates B-cell development and B-cell receptor signaling.
  3. NONO regulates multiple cytokine production in sepsis via the ERK1/2 signaling pathway.
    Title: NONO regulates multiple cytokine production in sepsis via the ERK1/2 signaling pathway.
  4. Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention.
    Title: Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention.
  5. A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells.
    Title: A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells.
  6. Transcriptional silencing of fetal hemoglobin expression by NonO.
    Title: Transcriptional silencing of fetal hemoglobin expression by NonO.
  7. Knockout of the NONO Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury.
    Title: Knockout of the NONO Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury.
  8. Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.
    Title: Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.
  9. G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA.
    Title: G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA.
  10. Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells.
    Title: Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (4) 
  • Endonuclease-mediated (9)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103109

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lncRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to angiotensin ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in paraspeckles ISO
Inferred from Sequence Orthology
more info
  
located_in paraspeckles ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
non-POU domain-containing octamer-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252518.2 → NP_001239447.1  non-POU domain-containing octamer-binding protein isoform a

    See identical proteins and their annotated locations for NP_001239447.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL831722
    Consensus CDS
    CCDS30316.1
    UniProtKB/Swiss-Prot
    Q63887, Q99K48, Q9CYQ4, Q9DBP2
    UniProtKB/TrEMBL
    Q3TFC2, Q3TTV7, Q4FK11
    Conserved Domains (3) summary
    cd12946
    Location:221 → 313
    NOPS_p54nrb_PSF_PSPC1; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSPC1 family proteins
    cd12588
    Location:75 → 145
    RRM1_p54nrb; RNA recognition motif 1 in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
    cl17169
    Location:151 → 230
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001426220.1 → NP_001413149.1  non-POU domain-containing octamer-binding protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AL831722

  3. NM_001426221.1 → NP_001413150.1  non-POU domain-containing octamer-binding protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AL831722

  4. NM_023144.3 → NP_075633.2  non-POU domain-containing octamer-binding protein isoform a

    See identical proteins and their annotated locations for NP_075633.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL831722
    Consensus CDS
    CCDS30316.1
    UniProtKB/Swiss-Prot
    Q63887, Q99K48, Q9CYQ4, Q9DBP2
    UniProtKB/TrEMBL
    Q3TFC2, Q3TTV7, Q4FK11
    Related
    ENSMUSP00000033673.7, ENSMUST00000033673.7
    Conserved Domains (3) summary
    cd12946
    Location:221 → 313
    NOPS_p54nrb_PSF_PSPC1; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSPC1 family proteins
    cd12588
    Location:75 → 145
    RRM1_p54nrb; RNA recognition motif 1 in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
    cl17169
    Location:151 → 230
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    100473295..100492193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99K48.3 GenPept UniProtKB/Swiss-Prot:Q99K48

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