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Snrpa small nuclear ribonucleoprotein polypeptide A [ Mus musculus (house mouse) ]

Gene ID: 53607, updated on 5-Mar-2024

Summary

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Official Symbol
Snrpaprovided by MGI
Official Full Name
small nuclear ribonucleoprotein polypeptide Aprovided by MGI
Primary source
MGI:MGI:1855690
See related
Ensembl:ENSMUSG00000061479 AllianceGenome:MGI:1855690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U1A; U1-A; Rnu1a1; Rnu1a-1; C430021M15Rik
Summary
Predicted to enable U1 snRNA binding activity; U1 snRNP binding activity; and identical protein binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of mRNA polyadenylation. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of U1 snRNP and spliceosomal complex. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA (small nuclear ribonucleoprotein polypeptide A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 95.1), limb E14.5 (RPKM 88.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 15.84 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26886431..26895696, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27187006..27196271, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RAB4B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancers ABC_E1725 and ABC_E288 Neighboring gene microRNA 3101 Neighboring gene MIA SH3 domain containing Neighboring gene STARR-positive B cell enhancer ABC_E3707 Neighboring gene actin maturation protease Neighboring gene microRNA 1191 Neighboring gene inositol 1,4,5-trisphosphate 3-kinase C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence analysis of the A protein of the U1 small nuclear ribonucleoprotein particle: the murine protein contains a 5' amino-terminal tag. Bennett MM, et al. Nucleic Acids Res, 1993 Sep 11. PMID 8415008, Free PMC Article
  2. Non-snRNP U1A levels decrease during mammalian B-cell differentiation and release the IgM secretory poly(A) site from repression. Ma J, et al. RNA, 2006 Jan. PMID 16373497, Free PMC Article
  3. Tissue-restricted expression of the Cdrap/Mia gene within a conserved multigenic housekeeping locus. Davies SR, et al. Genomics, 2004 Apr. PMID 15028289
  4. SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing. Subramania S, et al. Nucleic Acids Res, 2019 May 7. PMID 30767021, Free PMC Article
  5. Mutation-adapted U1 snRNA corrects a splicing error of the dopa decarboxylase gene. Lee NC, et al. Hum Mol Genet, 2016 Dec 1. PMID 27658936

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing.
    Title: SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing.
  2. We found that only the modified U1 snRNA (IVS-AAA) that completely matched both the intronic and exonic U1 binding sequences of the mutated DDC gene could correct splicing errors of either the mutated human DDC minigene or the mouse artificial splicing construct in vitro
    Title: Mutation-adapted U1 snRNA corrects a splicing error of the dopa decarboxylase gene.
  3. a new mechanism for regulating SMN levels and provides new insight into the roles of U1A in 3' processing of mRNAs.
    Title: U1A regulates 3' processing of the survival motor neuron mRNA.
  4. Endogenous non-snRNP associated U1A inhibits poly(A) polymerase activity proportional to U1A recovered, suggesting that available U1A level alone is responsible for changes in its inhibitory effect at the secretory IgM poly (A) site.
    Title: Non-snRNP U1A levels decrease during mammalian B-cell differentiation and release the IgM secretory poly(A) site from repression.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U1 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U1 snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U1 snRNP binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U1 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U1 small nuclear ribonucleoprotein A
Names
U1 snRNP A
protein A of the U1 small nuclear RNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001046637.1 → NP_001040102.1  U1 small nuclear ribonucleoprotein A

    See identical proteins and their annotated locations for NP_001040102.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC157561, AI851424, AW541778, CX565356
    Consensus CDS
    CCDS21014.1
    UniProtKB/Swiss-Prot
    Q52LA2, Q62189
    UniProtKB/TrEMBL
    Q9CXX7
    Related
    ENSMUSP00000131897.3, ENSMUST00000163311.9
    Conserved Domains (3) summary
    COG0724
    Location:7 → 122
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12477
    Location:13 → 101
    RRM1_U1A; RNA recognition motif 1 found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
    cd12480
    Location:208 → 287
    RRM2_U1A; RNA recognition motif 2 found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)

  2. NM_001285825.1 → NP_001272754.1  U1 small nuclear ribonucleoprotein A

    See identical proteins and their annotated locations for NP_001272754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI851424, CA552113, CX206945, DV650448
    Consensus CDS
    CCDS21014.1
    UniProtKB/Swiss-Prot
    Q52LA2, Q62189
    UniProtKB/TrEMBL
    Q9CXX7
    Related
    ENSMUSP00000113678.2, ENSMUST00000122202.8
    Conserved Domains (3) summary
    COG0724
    Location:7 → 122
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12477
    Location:13 → 101
    RRM1_U1A; RNA recognition motif 1 found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
    cd12480
    Location:208 → 287
    RRM2_U1A; RNA recognition motif 2 found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)

  3. NM_015782.3 → NP_056597.3  U1 small nuclear ribonucleoprotein A

    See identical proteins and their annotated locations for NP_056597.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI851424, BC096648, CX206945
    Consensus CDS
    CCDS21014.1
    UniProtKB/Swiss-Prot
    Q52LA2, Q62189
    UniProtKB/TrEMBL
    Q9CXX7
    Related
    ENSMUSP00000079228.4, ENSMUST00000080356.10
    Conserved Domains (3) summary
    COG0724
    Location:7 → 122
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12477
    Location:13 → 101
    RRM1_U1A; RNA recognition motif 1 found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
    cd12480
    Location:208 → 287
    RRM2_U1A; RNA recognition motif 2 found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    26886431..26895696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62189.3 GenPept UniProtKB/Swiss-Prot:Q62189

Gene LinkOut

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