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SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Bos taurus (cattle) ]

Gene ID: 535742, updated on 5-Mar-2024

Summary

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Official Symbol
SRCprovided by VGNC
Official Full Name
SRC proto-oncogene, non-receptor tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:35269
See related
BGD:BT11155; Ensembl:ENSBTAG00000008938
Gene type
protein coding
RefSeq status
INFERRED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (66295502..66350615)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene mannosidase beta like Neighboring gene uncharacterized LOC100849067 Neighboring gene BLCAP apoptosis inducing factor Neighboring gene neuronatin Neighboring gene catenin beta like 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Wang Y, et al. Proc Natl Acad Sci U S A, 2006 Feb 7. PMID 16446427, Free PMC Article
  2. Cyclic strain activates redox-sensitive proline-rich tyrosine kinase 2 (PYK2) in endothelial cells. Cheng JJ, et al. J Biol Chem, 2002 Dec 13. PMID 12368297
  3. RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress. Liu B, et al. Sci Rep, 2014 Nov 12. PMID 25387906, Free PMC Article
  4. Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production. Olala LO, et al. Mol Cell Endocrinol, 2014 Jul 5. PMID 24859649, Free PMC Article
  5. Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src. Lee YH, et al. Am J Respir Cell Mol Biol, 2007 Oct. PMID 17585111, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress.
    Title: RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress.
  2. AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
    Title: Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production.
  3. The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.
    Title: Correlation analysis between three novel SNPs of the Src gene in bovine and milk production traits.
  4. These results suggest that TGF-beta1-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src-dependent and -independent pathways.
    Title: Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src.
  5. results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
    Title: Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in bone resorption IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in osteoclast development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in progesterone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proto-oncogene tyrosine-protein kinase Src
Names
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
NP_001104274.1
XP_005214861.1
XP_005214862.1
XP_005214863.2
XP_010809812.2
XP_010809813.2
XP_059748695.1
XP_059748696.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110804.2 → NP_001104274.1  proto-oncogene tyrosine-protein kinase Src

    See identical proteins and their annotated locations for NP_001104274.1

    Status: INFERRED

    Source sequence(s)
    NKLS02000013
    UniProtKB/TrEMBL
    E1BIM8
    Related
    ENSBTAP00000060992.2, ENSBTAT00000072313.2
    Conserved Domains (3) summary
    cd10365
    Location:153 → 253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:94 → 149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266 → 542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    66295502..66350615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005214806.5 → XP_005214863.2  proto-oncogene tyrosine-protein kinase Src isoform X1

  2. XM_010811510.4 → XP_010809812.2  proto-oncogene tyrosine-protein kinase Src isoform X2

  3. XM_010811511.4 → XP_010809813.2  proto-oncogene tyrosine-protein kinase Src isoform X3

    UniProtKB/TrEMBL
    E1BIM8
    Related
    ENSBTAP00000011767.4, ENSBTAT00000011767.5

  4. XM_059892712.1 → XP_059748695.1  proto-oncogene tyrosine-protein kinase Src isoform X4

  5. XM_005214804.5 → XP_005214861.1  proto-oncogene tyrosine-protein kinase Src isoform X4

    See identical proteins and their annotated locations for XP_005214861.1

    Conserved Domains (4) summary
    cd10365
    Location:170 → 270
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:94 → 166
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:283 → 559
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    pfam07714
    Location:293 → 542
    Pkinase_Tyr; Protein tyrosine kinase

  6. XM_005214805.5 → XP_005214862.1  proto-oncogene tyrosine-protein kinase Src isoform X4

    See identical proteins and their annotated locations for XP_005214862.1

    Conserved Domains (4) summary
    cd10365
    Location:170 → 270
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:94 → 166
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:283 → 559
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    pfam07714
    Location:293 → 542
    Pkinase_Tyr; Protein tyrosine kinase

  7. XM_059892713.1 → XP_059748696.1  proto-oncogene tyrosine-protein kinase Src isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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