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Ilk Integrin linked kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53573, updated on 4-Apr-2024

Summary

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Official Symbol
Ilkprovided by FlyBase
Official Full Name
Integrin linked kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0028427
Locus tag
Dmel_CG10504
See related
AllianceGenome:FB:FBgn0028427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10504; CT29478; Dmel\CG10504; DmILK; ilk; ILK; l(3)78Ca
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces; cell-matrix adhesion; and muscle attachment. Located in focal adhesion. Is expressed in several structures, including adult CNS glial cell; circulatory system; extended germ band embryo; germ layer; and muscle system. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ILK (integrin linked kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
78C2-78C2; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21216901..21219240)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21210001..21212340)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA methyltransferase subunit 11-2 Neighboring gene uncharacterized protein Neighboring gene Ecdysone-induced protein 78C Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH, and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.
    Title: Integrin Adhesions Suppress Syncytium Formation in the Drosophila Larval Epidermis.
  2. PINCH and ILK have an independent capacity to localize at muscle attachment sites in vivo.
    Title: A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted.
  3. ILK functions as an essential hub in the assembly of its partner proteins at sites of integrin adhesion.
    Title: A central multifunctional role of integrin-linked kinase at muscle attachment sites.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables protein kinase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
colocalizes_with stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
integrin linked kinase
Names
CG10504-PA
CG10504-PB
Ilk-PA
Ilk-PB
Integrin-linked kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21216901..21219240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080262.4 → NP_525001.2  integrin linked kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525001.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NHC7, Q9V400
    Related
    FBpp0077962
    Conserved Domains (5) summary
    smart00221
    Location:204 → 443
    STYKc; Protein kinase; unclassified specificity
    cd00204
    Location:28 → 140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:196 → 446
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    pfam12796
    Location:38 → 130
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:33 → 64
    ANK; ANK repeat [structural motif]

  2. NM_001259931.1 → NP_001246860.1  integrin linked kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246860.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3CTS5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E3CTS5 E3CTS5
Q9NHC7 Q9NHC7
Q9V400 Q9V400

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