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SC35 SR family splicing factor SC35 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53444, updated on 10-May-2024

Summary

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Official Symbol
SC35provided by FlyBase
Official Full Name
SR family splicing factor SC35provided by FlyBase
Primary source
FLYBASE:FBgn0265298
Locus tag
Dmel_CG5442
See related
AllianceGenome:FB:FBgn0265298
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey284; CG15494; cg5442; CG5442; CG5542; Dmel\CG5442; dSC35; SC-35; sc35; Sc35
Summary
Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome; regulation of mRNA 3'-end processing; and regulation of transcriptional start site selection at RNA polymerase II promoter. Located in chromatin and nuclear speck. Is expressed in several structures, including adult heart; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and extended germ band embryo. Human ortholog(s) of this gene implicated in acute myeloid leukemia; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to several human genes including SRSF2 (serine and arginine rich splicing factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
33E4-33E4; 2-46 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12431075..12434665, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12431075..12434665, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA methyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene eukaryotic translation release factor 3 Neighboring gene Organic anion transporting polypeptide 33Ea Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation status of the Kep1 protein alters its affinity for its protein binding partner alternative splicing factor ASF/SF2. Robard C, et al. Biochem J, 2006 Nov 15. PMID 16834570, Free PMC Article
  2. Spargel/dPGC-1 is a new downstream effector in the insulin-TOR signaling pathway in Drosophila. Mukherjee S, et al. Genetics, 2013 Oct. PMID 23934892, Free PMC Article
  3. The splicing regulators Tra and Tra2 are unusually potent activators of pre-mRNA splicing. Sciabica KS, et al. Nucleic Acids Res, 2006. PMID 17135210, Free PMC Article
  4. Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila. Prasanth KV, et al. J Cell Sci, 2000 Oct. PMID 10984439
  5. The SR protein B52/SRp55 regulates splicing of the period thermosensitive intron and mid-day siesta in Drosophila. Zhang Z, et al. Sci Rep, 2018 Jan 30. PMID 29382842, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SR family splicing factor SC35
Names
CG5442-PA
CG5442-PB
CG5442-PC
CG5442-PD
SC35-PA
SC35-PB
SC35-PC
SC35-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12431075..12434665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201865.2 → NP_001188794.1  SR family splicing factor SC35, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188794.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C547, Q9V3T8, Q9VK86
    Conserved Domains (2) summary
    COG0724
    Location:24 → 100
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12311
    Location:25 → 97
    RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

  2. NM_001259076.2 → NP_001246005.1  SR family splicing factor SC35, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246005.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C547, Q9V3T8, Q9VK86
    Conserved Domains (2) summary
    COG0724
    Location:24 → 100
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12311
    Location:25 → 97
    RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

  3. NM_205967.2 → NP_995689.1  SR family splicing factor SC35, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995689.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTD2

  4. NM_144355.4 → NP_652612.1  SR family splicing factor SC35, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652612.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C547, Q9V3T8, Q9VK86
    Related
    FBpp0088838
    Conserved Domains (2) summary
    COG0724
    Location:24 → 100
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12311
    Location:25 → 97
    RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KTD2 Q7KTD2
Q9V3T8 Q9V3T8

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