U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SF2 Splicing factor 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53443, updated on 10-May-2024

Summary

Go to the top of the page Help
Official Symbol
SF2provided by FlyBase
Official Full Name
Splicing factor 2provided by FlyBase
Primary source
FLYBASE:FBgn0283477
Locus tag
Dmel_CG6987
See related
AllianceGenome:FB:FBgn0283477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
154911_at; ASF; ASF/SF2; cg6987; CG6987; dASF; Dmel\CG6987; dmSF2/p28; dSF2; dSF2/ASF; dSRp30; Sf2; SRp30; SRSF1
Summary
Enables DNA binding activity and mRNA binding activity. Involved in RNA export from nucleus and regulation of RNA metabolic process. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult heart; embryonic/larval midgut; embryonic/larval nervous system; extended germ band embryo; and ring gland. Orthologous to several human genes including SRSF1 (serine and arginine rich splicing factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
89B13-89B13; 3-58 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16338943..16341988, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12164665..12167710, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sulfated Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene poils au dos Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mesencephalic astrocyte-derived neurotrophic factor

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Drosophila splicing factor SF2 knock-down mutant shows altered cell-cycle in vivo. Dubatolova TD, et al. Cell Biol Int, 2013 Feb. PMID 23319380
  2. SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis. Castelli LM, et al. Mol Neurodegener, 2021 Aug 10. PMID 34376242, Free PMC Article
  3. Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position. Shen M, et al. Nucleic Acids Res, 2012 Jan. PMID 21914724, Free PMC Article
  4. Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation. Lin S, et al. Mol Cell, 2005 Nov 11. PMID 16285923
  5. The Drosophila heterogeneous nuclear ribonucleoprotein M protein, HRP59, regulates alternative splicing and controls the production of its own mRNA. Hase ME, et al. J Biol Chem, 2006 Dec 22. PMID 17077090

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.
    Title: TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.
  2. The splicing factors proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila.
    Title: The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila.
  3. Drosophila splicing factor SF2 knock-down mutant shows altered cell-cycle in vivo
    Title: Drosophila splicing factor SF2 knock-down mutant shows altered cell-cycle in vivo.
  4. The SR proteins dASF/SF2 and B52 caused defects in ommatidia structure, and B52 impaired normal axonal projections of photoreceptors and neurogenesis in visual ganglia.
    Title: The SR family proteins B52 and dASF/SF2 modulate development of the Drosophila visual system by regulating specific RNA targets.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
splicing factor 2
Names
CG6987-PA
CG6987-PB
SF2-PA
SF2-PB
SRp30

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16338943..16341988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260210.2 → NP_001247139.1  splicing factor 2, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3W7
    Conserved Domains (2) summary
    cd12601
    Location:115 → 188
    RRM2_SRSF1_like; RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor SRSF1, SRSF9 and similar proteins
    cl17169
    Location:3 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_144354.3 → NP_652611.1  splicing factor 2, isoform A [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3W7
    Related
    FBpp0082724
    Conserved Domains (2) summary
    cd12601
    Location:115 → 188
    RRM2_SRSF1_like; RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor SRSF1, SRSF9 and similar proteins
    cl17169
    Location:3 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3W7 Q9V3W7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous