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Mybph myosin binding protein H [ Mus musculus (house mouse) ]

Gene ID: 53311, updated on 12-Mar-2024

Summary

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Official Symbol
Mybphprovided by MGI
Official Full Name
myosin binding protein Hprovided by MGI
Primary source
MGI:MGI:1858196
See related
Ensembl:ENSMUSG00000042451 AllianceGenome:MGI:1858196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MyBP-H
Summary
Predicted to act upstream of or within cell adhesion. Predicted to be located in myosin filament. Is expressed in diaphragm; limb; skeletal musculature; and tail mesenchyme. Orthologous to human MYBPH (myosin binding protein H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 27.1), limb E14.5 (RPKM 24.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 58.15 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134121159..134128975)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134193418..134201237)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46158 Neighboring gene STARR-seq mESC enhancer starr_02318 Neighboring gene chitinase 3 like 1 Neighboring gene STARR-positive B cell enhancer ABC_E1561 Neighboring gene adenosine A1 receptor Neighboring gene predicted gene, 32221 Neighboring gene STARR-seq mESC enhancer starr_02321 Neighboring gene predicted gene, 24517 Neighboring gene myogenin promoter-associated myogenic regulatory antisense lncRNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice. Hayashi S, et al. Elife, 2016 Oct 15. PMID 27743478, Free PMC Article
  2. Extraocular muscle morphogenesis and gene expression are regulated by Pitx2 gene dose. Diehl AG, et al. Invest Ophthalmol Vis Sci, 2006 May. PMID 16638982
  3. The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Gómez-Del Arco P, et al. Cell Metab, 2016 May 10. PMID 27166947
  4. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144854, MGC144855

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin-binding protein H
Names
H-protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357515.1 → NP_001344444.1  myosin-binding protein H

    Status: VALIDATED

    Source sequence(s)
    AC137104
    Consensus CDS
    CCDS35713.1
    UniProtKB/Swiss-Prot
    E9QKH7, P70402
    UniProtKB/TrEMBL
    Q148P3
    Conserved Domains (3) summary
    cd00063
    Location:77 → 163
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:388 → 477
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:197 → 269
    Ig; Immunoglobulin domain

  2. NM_016749.2 → NP_058029.2  myosin-binding protein H

    See identical proteins and their annotated locations for NP_058029.2

    Status: VALIDATED

    Source sequence(s)
    AA673795, CB587371, U68267
    Consensus CDS
    CCDS35713.1
    UniProtKB/Swiss-Prot
    E9QKH7, P70402
    UniProtKB/TrEMBL
    Q148P3
    Related
    ENSMUSP00000042195.7, ENSMUST00000038445.13
    Conserved Domains (3) summary
    cd00063
    Location:77 → 163
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:388 → 477
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:197 → 269
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134121159..134128975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529753.4 → XP_006529816.1  myosin-binding protein H isoform X1

    UniProtKB/TrEMBL
    Q148P3
    Conserved Domains (3) summary
    cd00063
    Location:77 → 163
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:388 → 477
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:197 → 269
    Ig; Immunoglobulin domain

RNA

  1. XR_003956241.2 RNA Sequence

  2. XR_003956240.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70402.2 GenPept UniProtKB/Swiss-Prot:P70402

Gene LinkOut

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