CDC42 cell division cycle 42 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: CDC42provided by VGNC
Official Full Name: cell division cycle 42provided by VGNC
Primary source: VGNC:VGNC:97251
See related: Ensembl:ENSBTAG00000001700
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (130733638..130754601, complement)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study revealed a novel signaling pathway activated during M. avium subsp. paratuberculosis entry that links the product of MAP3464 gene to activation of Cdc42 in the host cell.
Title: The Mycobacterium avium subsp. paratuberculosis MAP3464 gene encodes an oxidoreductase involved in invasion of bovine epithelial cells through the activation of host cell Cdc42.
These data are consistent with the idea that migrating corneal epithelial cells use a cdc42/rho "switch" to sort vectoral cues, with cdc42 controlling electrotaxis and rho controlling contact guidance.
Title: Prioritising guidance cues: directional migration induced by substratum contours and electrical gradients is controlled by a rho/cdc42 switch.
shear-stimulated integrin dynamics induce polarized Cdc42 activity, which induces MTOC localization through the Par6-protein kinase Czeta complex.
Title: Localized cdc42 activation, detected using a novel assay, mediates microtubule organizing center positioning in endothelial cells in response to fluid shear stress.

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General gene information

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Markers

RH69132 (e-PCR)
- UniSTS:30736

MARC_13883-13884:1007561107:1 (e-PCR)
- UniSTS:267593

MARC_13883-13884:1032803483:5 (e-PCR)
- UniSTS:267593

CDC42_1530 (e-PCR)
- UniSTS:277081

MARC_9695-9696:996688531:1 (e-PCR)
- UniSTS:269973

CDC42 (e-PCR)
- UniSTS:278181

SHGC-74349 (e-PCR)
- UniSTS:58308

UniSTS:224478 (e-PCR)
- UniSTS:224478

G34846 (e-PCR)
- UniSTS:72173

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in modification of synaptic structure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in dendritic spine	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cell division control protein 42 homolog

Names: cell division cycle 42 (GTP binding protein, 25kDa)

NP_001039797.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001046332.1 → NP_001039797.1 cell division control protein 42 homolog

See identical proteins and their annotated locations for NP_001039797.1

Status: PROVISIONAL

Source sequence(s)

BC105461

UniProtKB/Swiss-Prot

Q2KJ93

UniProtKB/TrEMBL

B6VAP7

Related

ENSBTAP00000065017.2, ENSBTAT00000069072.2

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family