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PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [ Bos taurus (cattle) ]

Gene ID: 530001, updated on 5-Mar-2024

Summary

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Official Symbol
PIK3CGprovided by VGNC
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaprovided by VGNC
Primary source
VGNC:VGNC:32892
See related
BGD:BT26617; Ensembl:ENSBTAG00000020848
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (47988414..48024313)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104972036 Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene coiled-coil domain containing 71 like Neighboring gene uncharacterized LOC132345085 Neighboring gene uncharacterized LOC112446374 Neighboring gene large ribosomal subunit protein uL22m-like Neighboring gene uncharacterized LOC104972045

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC157122

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IA IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IB IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Names
phosphoinositide-3-kinase, catalytic, gamma polypeptide
NP_001095595.1
XP_005205479.1
XP_005205480.1
XP_005205481.1
XP_024846505.1
XP_059741607.1
XP_059741608.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102125.2 → NP_001095595.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

    See identical proteins and their annotated locations for NP_001095595.1

    Status: PROVISIONAL

    Source sequence(s)
    BC149468
    UniProtKB/TrEMBL
    A6QPT0
    Conserved Domains (4) summary
    cd08399
    Location:350 → 527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203 → 312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549 → 725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cl21453
    Location:729 → 877
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    47988414..48024313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005205424.5 → XP_005205481.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

    See identical proteins and their annotated locations for XP_005205481.1

    UniProtKB/TrEMBL
    A0A3Q1M2L5
    Conserved Domains (4) summary
    cd08399
    Location:350 → 527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    cd00872
    Location:549 → 725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:729 → 1095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    pfam00794
    Location:203 → 312
    PI3K_rbd; PI3-kinase family, ras-binding domain

  2. XM_059885624.1 → XP_059741607.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M2L5

  3. XM_024990737.2 → XP_024846505.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M2L5
    Conserved Domains (4) summary
    cd08399
    Location:350 → 527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    cd00872
    Location:549 → 725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:729 → 1095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    pfam00794
    Location:203 → 312
    PI3K_rbd; PI3-kinase family, ras-binding domain

  4. XM_005205422.5 → XP_005205479.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

    See identical proteins and their annotated locations for XP_005205479.1

    UniProtKB/TrEMBL
    A0A3Q1M2L5
    Conserved Domains (4) summary
    cd08399
    Location:350 → 527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    cd00872
    Location:549 → 725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:729 → 1095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    pfam00794
    Location:203 → 312
    PI3K_rbd; PI3-kinase family, ras-binding domain

  5. XM_005205423.5 → XP_005205480.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

    See identical proteins and their annotated locations for XP_005205480.1

    UniProtKB/TrEMBL
    A0A3Q1M2L5
    Related
    ENSBTAP00000027780.5, ENSBTAT00000027780.6
    Conserved Domains (4) summary
    cd08399
    Location:350 → 527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    cd00872
    Location:549 → 725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:729 → 1095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    pfam00794
    Location:203 → 312
    PI3K_rbd; PI3-kinase family, ras-binding domain

  6. XM_059885625.1 → XP_059741608.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

    UniProtKB/TrEMBL
    A6QPT0
Nucleotide Protein Strain
Heading Accession and Version

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