ADORA2B adenosine A2b receptor [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ADORA2Bprovided by VGNC
Official Full Name: adenosine A2b receptorprovided by VGNC
Primary source: VGNC:VGNC:25688
See related: BGD:BT13602
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (33482082..33502631, complement)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Purinergic stimulation of cilia beat frequency requires A(2B) adenosine receptor activation, likely via protein kinase A-dependent pathway.
Title: Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance.
It is likely that adenosine acts through A(2B) receptors and adenylyl cyclases to stimulate CNGA2.
Title: CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vasodilation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: adenosine receptor A2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001075925.1 → NP_001069393.1 adenosine receptor A2b

See identical proteins and their annotated locations for NP_001069393.1

Status: PROVISIONAL

Source sequence(s)

BC116078

UniProtKB/Swiss-Prot

Q1LZD0

Conserved Domains (2) summary

pfam00001
Location:24 → 289

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:21 → 134

7tm_4; Olfactory receptor