Pum3 pumilio RNA-binding family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pum3provided by MGI
Official Full Name: pumilio RNA-binding family member 3provided by MGI
Primary source: MGI:MGI:106253
See related: Ensembl:ENSMUSG00000041360 AllianceGenome:MGI:106253
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D19Bwg1357e; 1110069H02Rik
Summary: This gene encodes a member of the evolutionarily conserved Pumilio and Fem-3 mRNA-binding factor family of proteins, which are characterized by tandem 36 amino acid pumilio homolog domains and which function in diverse biological processes. This protein belongs to a group of atypical Pumilio and Fem-3 mRNA-binding factor proteins, whose members are distinguished from other Pumilio and Fem-3 mRNA-binding factor proteins by a novel protein fold with 11 pumilio homolog domains and an ability to bind to DNA and single- and double-stranded RNA without sequence specificity. In mouse, lower levels of gene expression have been correlated with increased testicular germ cell tumors. A pseudogene of this gene is found on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.7), placenta adult (RPKM 9.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 21.96 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (27366105..27407264, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (27388698..27429908, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pum3 is dispensable for mouse oocyte maturation and embryo development in vitro.
Title: Pum3 is dispensable for mouse oocyte maturation and embryo development in vitro.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB464475 (e-PCR)
- UniSTS:209451

RH125049 (e-PCR)
- UniSTS:161871

RH124546 (e-PCR)
- UniSTS:161368

D19Bwg1357e (e-PCR), detects polymorphism
- UniSTS:142206

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of protein ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pumilio homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403084.1 → NP_001390013.1 pumilio homolog 3

Status: VALIDATED

Source sequence(s)

AC124973

UniProtKB/TrEMBL

A0A0N4SUH4
NM_177474.6 → NP_803425.1 pumilio homolog 3

See identical proteins and their annotated locations for NP_803425.1

Status: VALIDATED

Source sequence(s)

AC124973

Consensus CDS

CCDS29723.1

UniProtKB/Swiss-Prot

Q6A0E6, Q8BKS9, Q8BU15

UniProtKB/TrEMBL

A0A0N4SUH4

Related

ENSMUSP00000075573.5, ENSMUST00000076219.6

Conserved Domains (2) summary

cl29546
Location:182 → 387

Pumilio; Pumilio-family RNA binding domain

pfam08144
Location:434 → 571

CPL; CPL (NUC119) domain