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JAK2 Janus kinase 2 [ Bos taurus (cattle) ]

Gene ID: 525246, updated on 11-Apr-2024

Summary

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Official Symbol
JAK2provided by VGNC
Official Full Name
Janus kinase 2provided by VGNC
Primary source
VGNC:VGNC:30365
See related
BGD:BT10737; Ensembl:ENSBTAG00000012047
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See JAK2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (39380542..39498855, complement)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene 26S proteasome regulatory subunit 10B-like Neighboring gene insulin like 6 Neighboring gene RNA terminal phosphate cyclase like 1 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene uncharacterized LOC132345947

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association of a genetic marker at the bovine Janus kinase 2 locus (JAK2/RsaI) with milk production traits of four cattle breeds. Szewczuk M. J Dairy Res, 2015 Aug. PMID 26119533
  2. Caveolae nitration of Janus kinase-2 at the 1007Y-1008Y site: coordinating inflammatory response and metabolic hormone readjustment within the somatotropic axis. Elsasser TH, et al. Endocrinology, 2007 Aug. PMID 17510231
  3. Mechanisms of endothelial cell protection by blockade of the JAK2 pathway. Neria F, et al. Am J Physiol Cell Physiol, 2007 Mar. PMID 17035297
  4. Significant genetic effects of JAK2 and DGAT1 mutations on milk fat content and mastitis resistance in Holsteins. Khan MZ, et al. J Dairy Res, 2019 Nov. PMID 31779717
  5. Association study of single nucleotide polymorphisms in JAK2 and STAT5B genes and their differential mRNA expression with mastitis susceptibility in Chinese Holstein cattle. Usman T, et al. Anim Genet, 2015 Aug. PMID 26154111

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings demonstrated that milk fat percentage, somatic cell count (SCC), somatic cell score (SCS), serum cytokines interleukin 6 (IL-6) and interferon gamma (IFN-gamma) showed significant associations (P < 0.05) with at least one or more identified single nucleotide polymorphisms (SNPs).
    Title: Significant genetic effects of JAK2 and DGAT1 mutations on milk fat content and mastitis resistance in Holsteins.
  2. Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
    Title: Association of a genetic marker at the bovine Janus kinase 2 locus (JAK2/RsaI) with milk production traits of four cattle breeds.
  3. Results indicate that SNPs in STAT5A and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
    Title: Genetic effects of single nucleotide polymorphisms in JAK2 and STAT5A genes on susceptibility of Chinese Holsteins to mastitis.
  4. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 and mTOR signaling pathways.
    Title: Methionyl-Methionine Promotes α-s1 Casein Synthesis in Bovine Mammary Gland Explants by Enhancing Intracellular Substrate Availability and Activating JAK2-STAT5 and mTOR-Mediated Signaling Pathways.
  5. SNPs in JAK2 and STAT5B are associated with mastitis susceptibility in Chinese Holstein cattle
    Title: Association study of single nucleotide polymorphisms in JAK2 and STAT5B genes and their differential mRNA expression with mastitis susceptibility in Chinese Holstein cattle.
  6. Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
    Title: Caveolae nitration of Janus kinase-2 at the 1007Y-1008Y site: coordinating inflammatory response and metabolic hormone readjustment within the somatotropic axis.
  7. These applications affect not only EC in the monolayer but also circulating detached cells and involve mechanistic interactions not previously described.
    Title: Mechanisms of endothelial cell protection by blockade of the JAK2 pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK2
Names
Janus kinase 2 (a protein tyrosine kinase)
XP_003586433.1
XP_005210038.1
XP_024851895.1
XP_024851896.1
XP_024851897.1
XP_059745535.1
XP_059745536.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    39380542..39498855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024996127.2 → XP_024851895.1  tyrosine-protein kinase JAK2 isoform X2

    Conserved Domains (5) summary
    cd10379
    Location:303 → 399
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:1 → 187
    B41; Band 4.1 homologues
    cd13333
    Location:183 → 303
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:462 → 723
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:761 → 1044
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  2. XM_005209981.5 → XP_005210038.1  tyrosine-protein kinase JAK2 isoform X1

    See identical proteins and their annotated locations for XP_005210038.1

    UniProtKB/TrEMBL
    E1BCP6
    Related
    ENSBTAP00000088916.1, ENSBTAT00000129682.1
    Conserved Domains (5) summary
    cd10379
    Location:386 → 482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:38 → 270
    B41; Band 4.1 homologues
    cd13333
    Location:266 → 386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545 → 806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:844 → 1127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  3. XM_003586385.6 → XP_003586433.1  tyrosine-protein kinase JAK2 isoform X1

    See identical proteins and their annotated locations for XP_003586433.1

    UniProtKB/TrEMBL
    E1BCP6
    Conserved Domains (5) summary
    cd10379
    Location:386 → 482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:38 → 270
    B41; Band 4.1 homologues
    cd13333
    Location:266 → 386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545 → 806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:844 → 1127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  4. XM_024996128.2 → XP_024851896.1  tyrosine-protein kinase JAK2 isoform X2

    Conserved Domains (5) summary
    cd10379
    Location:303 → 399
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:1 → 187
    B41; Band 4.1 homologues
    cd13333
    Location:183 → 303
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:462 → 723
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:761 → 1044
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  5. XM_024996129.2 → XP_024851897.1  tyrosine-protein kinase JAK2 isoform X2

    Conserved Domains (5) summary
    cd10379
    Location:303 → 399
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:1 → 187
    B41; Band 4.1 homologues
    cd13333
    Location:183 → 303
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:462 → 723
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:761 → 1044
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  6. XM_059889552.1 → XP_059745535.1  tyrosine-protein kinase JAK2 isoform X2

  7. XM_059889553.1 → XP_059745536.1  tyrosine-protein kinase JAK2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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