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PLA2G4A phospholipase A2 group IVA [ Bos taurus (cattle) ]

Gene ID: 525072, updated on 3-Apr-2024

Summary

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Official Symbol
PLA2G4Aprovided by VGNC
Official Full Name
phospholipase A2 group IVAprovided by VGNC
Primary source
VGNC:VGNC:32960
See related
BGD:BT16529; Ensembl:ENSBTAG00000013298
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Note: GeneID 525072 and 100850818 are annotated independently on Btau_4.6.1, but may be redundant. [17 Jun 2014]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (67907024..68081280)

Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene histone H2B type 1-C/E/F/G/I-like Neighboring gene prostaglandin-endoperoxide synthase 2 Neighboring gene potassium two pore domain channel subfamily K member 2 Neighboring gene transfer RNA valine (anticodon CAC) Neighboring gene cysteine dioxygenase type 1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a 42-kDa Group IV cPLA2-activating protein, cPLAPγ, as a GTP-binding protein in the bovine brain. Bach JH, et al. J Biochem, 2011 Oct. PMID 21613292
  2. Expression of phospholipase A2 group IVA (PLA2G4A) is upregulated by human chorionic gonadotropin in bovine granulosa cells of ovulatory follicles. Diouf MN, et al. Biol Reprod, 2006 Jun. PMID 16510840
  3. Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation. Gluck N, et al. Am J Physiol Cell Physiol, 2008 Jun. PMID 18385289
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. result suggests that cPLAPgamma may act as a G protein, activating cPLA(2)alpha prior to reaching full intracellular Ca(2 ) concentrations
    Title: Identification of a 42-kDa Group IV cPLA2-activating protein, cPLAPγ, as a GTP-binding protein in the bovine brain.
  2. Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation.
    Title: Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation.
  3. Ovulation is associated with an LH/hCG-dependent induction of PLA2G4A in GC via the adenylyl cyclase/cAMP pathway.
    Title: Expression of phospholipase A2 group IVA (PLA2G4A) is upregulated by human chorionic gonadotropin in bovine granulosa cells of ovulatory follicles.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycerophospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cytosolic phospholipase A2
Names
cPLA2
phospholipase A2, group IVA (cytosolic, calcium-dependent)
NP_001069332.1
XP_059731388.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075864.1 → NP_001069332.1  cytosolic phospholipase A2

    See identical proteins and their annotated locations for NP_001069332.1

    Status: PROVISIONAL

    Source sequence(s)
    AY363688
    UniProtKB/TrEMBL
    A0A3Q1LRP1
    Related
    ENSBTAP00000017685.3, ENSBTAT00000017685.5
    Conserved Domains (3) summary
    cd07200
    Location:144 → 730
    cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:20 → 138
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    smart00022
    Location:117 → 669
    PLAc; Cytoplasmic phospholipase A2, catalytic subunit

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    67907024..68081280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059875405.1 → XP_059731388.1  cytosolic phospholipase A2 isoform X1

    UniProtKB/Swiss-Prot
    A4IFJ5, Q1XD55
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4IFJ5.1 GenPept UniProtKB/Swiss-Prot:A4IFJ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.