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Ppp2r2d protein phosphatase 2, regulatory subunit B, delta [ Mus musculus (house mouse) ]

Gene ID: 52432, updated on 11-Apr-2024

Summary

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Official Symbol
Ppp2r2dprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B, deltaprovided by MGI
Primary source
MGI:MGI:1289252
See related
Ensembl:ENSMUSG00000041769 AllianceGenome:MGI:1289252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDS026; D7Ertd753e; 1300017E19Rik
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in peptidyl-serine dephosphorylation. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Is expressed in central nervous system and retina. Orthologous to human PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 18.0), whole brain E14.5 (RPKM 10.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F4; 7 82.95 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (138448073..138484786)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (138846350..138883057)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30874 Neighboring gene STARR-seq mESC enhancer starr_20408 Neighboring gene STARR-positive B cell enhancer ABC_E11741 Neighboring gene mitogen-activated protein kinase 1 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_20409 Neighboring gene STARR-seq mESC enhancer starr_20411 Neighboring gene STARR-seq mESC enhancer starr_20412 Neighboring gene BCL2/adenovirus E1B interacting protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E11372 Neighboring gene gamma-glutamyl hydrolase pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma. Pan W, et al. J Immunol, 2022 Aug 1. PMID 35831019, Free PMC Article
  2. In vivo discovery of immunotherapy targets in the tumour microenvironment. Zhou P, et al. Nature, 2014 Feb 6. PMID 24476824, Free PMC Article
  3. Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D. Kim YS, et al. Nat Commun, 2022 Oct 14. PMID 36241614, Free PMC Article
  4. PPP2R2D suppresses IL-2 production and Treg function. Pan W, et al. JCI Insight, 2020 Oct 2. PMID 32897879, Free PMC Article
  5. Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion. Veloso A, et al. Cell Death Dis, 2019 Jul 4. PMID 31273193, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
    Title: Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
  2. PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma.
    Title: PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma.
  3. PPP2R2D suppresses IL-2 production and Treg function.
    Title: PPP2R2D suppresses IL-2 production and Treg function.
  4. PP2A-B55delta as the first protein phosphatase to be involved in myoblast fusion and suggest that reversible phosphorylation of HDAC4 may coordinate differentiation and fusion events during myogenesis.
    Title: Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion.
  5. In tumours, Ppp2r2d knockdown inhibited T-cell apoptosis and enhanced T-cell proliferation as well as cytokine production
    Title: In vivo discovery of immunotherapy targets in the tumour microenvironment.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347618.1 → NP_001334547.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' end and uses a downstream start codon compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC149221
    Consensus CDS
    CCDS85447.1
    UniProtKB/TrEMBL
    F6RV17
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  2. NM_026391.2 → NP_080667.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform 1

    See identical proteins and their annotated locations for NP_080667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC066022
    Consensus CDS
    CCDS21950.1
    UniProtKB/Swiss-Prot
    Q6ZPN5, Q925E7
    Related
    ENSMUSP00000040321.7, ENSMUST00000041097.13
    Conserved Domains (2) summary
    COG5170
    Location:14 → 448
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:37 → 85
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    138448073..138484786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508015.3 → XP_006508078.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

    See identical proteins and their annotated locations for XP_006508078.1

    UniProtKB/TrEMBL
    F6RV17
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  2. XM_036153235.1 → XP_036009128.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

    UniProtKB/TrEMBL
    F6RV17
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  3. XM_030242762.2 → XP_030098622.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

    UniProtKB/TrEMBL
    F6RV17
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  4. XM_030242764.2 → XP_030098624.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

    UniProtKB/TrEMBL
    F6RV17
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  5. XM_017322350.3 → XP_017177839.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

    UniProtKB/TrEMBL
    F6RV17
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  6. XM_030242766.2 → XP_030098626.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

    UniProtKB/TrEMBL
    F6RV17
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  7. XM_006508020.5 → XP_006508083.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2

    Conserved Domains (2) summary
    COG5170
    Location:31 → 280
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:68 → 119
    7WD40; WD40 repeat [structural motif]

  8. XM_030242763.1 → XP_030098623.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

    UniProtKB/TrEMBL
    F6RV17
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  9. XM_036153233.1 → XP_036009126.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

    UniProtKB/TrEMBL
    F6RV17
    Related
    ENSMUSP00000119004.2, ENSMUST00000155672.8
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  10. XM_036153234.1 → XP_036009127.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

    UniProtKB/TrEMBL
    F6RV17
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925E7.1 GenPept UniProtKB/Swiss-Prot:Q925E7

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