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Echdc2 enoyl Coenzyme A hydratase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 52430, updated on 11-Apr-2024

Summary

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Official Symbol
Echdc2provided by MGI
Official Full Name
enoyl Coenzyme A hydratase domain containing 2provided by MGI
Primary source
MGI:MGI:1289238
See related
Ensembl:ENSMUSG00000028601 AllianceGenome:MGI:1289238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D4Ertd765e; 1300017C12Rik; 2610009M20Rik
Summary
Predicted to enable enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human ECHDC2 (enoyl-CoA hydratase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 56.0), kidney adult (RPKM 55.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Echdc2 in Genome Data Viewer
Location:
4 C7; 4 50.3 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108022630..108036505)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108165436..108179308)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene sterol carrier protein 2, liver Neighboring gene microRNA 6397 Neighboring gene STARR-seq mESC enhancer starr_11030 Neighboring gene STARR-seq mESC enhancer starr_11031 Neighboring gene STARR-seq mESC enhancer starr_11032 Neighboring gene predicted gene, 54248 Neighboring gene zyg-11 family member A, cell cycle regulator Neighboring gene STARR-seq mESC enhancer starr_11034 Neighboring gene predicted gene, 54249 Neighboring gene zyg-ll family member B, cell cycle regulator Neighboring gene STARR-positive B cell enhancer ABC_E2701

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  2. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
enoyl-CoA hydratase domain-containing protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001254754.1 → NP_001241683.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001241683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI839329, AK011365, AK166965, AL844206
    UniProtKB/Swiss-Prot
    Q3TLP5
    Conserved Domains (1) summary
    cl23717
    Location:1 → 191
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  2. NM_026728.4 → NP_081004.2  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_081004.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI839329, AK166965, AL844206
    Consensus CDS
    CCDS18447.2
    UniProtKB/Swiss-Prot
    A2APS6, Q3TKJ7, Q3TLP5, Q3TV08, Q3U553, Q8R3K4, Q9DBD3
    Related
    ENSMUSP00000051268.7, ENSMUST00000052999.13
    Conserved Domains (1) summary
    cl23717
    Location:42 → 296
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    108022630..108036505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320314.3 → XP_017175803.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3TLP5
    Conserved Domains (1) summary
    cl23717
    Location:1 → 191
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  2. XM_011240573.3 → XP_011238875.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011238875.1

    UniProtKB/Swiss-Prot
    Q3TLP5
    Conserved Domains (1) summary
    cl23717
    Location:1 → 191
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  3. XM_036164235.1 → XP_036020128.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    Q8R3H3
    Conserved Domains (1) summary
    cl23717
    Location:1 → 161
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RNA

  1. XR_003954983.1 RNA Sequence

    Related
    ENSMUST00000125647.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TLP5.2 GenPept UniProtKB/Swiss-Prot:Q3TLP5

Gene LinkOut

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